Protein Alignment CCKLR-17D1 and OPRM1

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001138751.1
• Gene: OPRM1 / 4988
• HGNCID: 8156
• Length: 493
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 110/555 - (19%)
• Similarity: 193/555 - (34%)
• Gaps: 201/555 - (36%)

  Fly    87 RQALPLAKEAAIHLNASNEISAVG-DGVTITGTPGDLLNYSGLELDLGLDLDLNLDMDLATTPSS 150
            |.|:.....:|...||||...|:. ...:...:||..:|.|        .||.||.....  |:.
Human    88 RPAVSTMDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLS--------HLDGNLSDPCG--PNR 142

  Fly   151 STLAPAVTVRTP-GNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFL 214
            :.|....::..| |:.|::     ..|.::..||.:.:..:.||.||:..:|:..:|:|.||:::
Human   143 TDLGGRDSLCPPTGSPSMI-----TAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYI 202

  Fly   215 LNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICH 279
            .|||::| .|....:|...|..|:..:.||.:|||::......::..|.:||..:|.:||.|:||
Human   203 FNLALAD-ALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCH 266

  Fly   280 PLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTS--RPGLRKCREQWPADSLNYERAY 342
            |:::..::|..:|..|....|:.|.....|:    ..|.|:  |.|...|...:...:..:|...
Human   267 PVKALDFRTPRNAKIINVCNWILSSAIGLPV----MFMATTKYRQGSIDCTLTFSHPTWYWENLL 327

  Fly   343 NLFLDLALLVLPLLALSFTY-LFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRAN 406
            .:.:.:...::|:|.::..| |.|.|
Human   328 KICVFIFAFIMPVLIITVCYGLMILR--------------------------------------- 353

  Fly   407 GSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLR 471
                                                                        :||:|
Human   354 ------------------------------------------------------------LKSVR 358

  Fly   472 HQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRS 536
                     .|||                               |:.|.
Human   359 ---------MLSG-------------------------------SKEKD---------------- 367

  Fly   537 NETKSLESKKRVVKMLFVLVLEFFICWTP--LYVINTMTMLLGPTVYEYVGYTSISFLQLLAYSS 599
                  .:.:|:.:|:.|:|..|.:||||  :|||....:.:..|.::.|.:   .|...|.|::
Human   368 ------RNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSW---HFCIALGYTN 423

  Fly   600 SCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAP 634
            ||.||:.|.|::.:|:|.|          ...|.|
Human   424 SCLNPVLYAFLDENFKRCF----------REFCIP 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	85/445 (19%)
		TM helix 1	178..202	CDD:410628	6/23 (26%)
		TM helix 2	211..233	CDD:410628	7/21 (33%)
		TM helix 3	249..271	CDD:410628	4/21 (19%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	3/23 (13%)
		TM helix 6	549..571	CDD:410628	11/23 (48%)
		TM helix 7	586..611	CDD:410628	9/24 (38%)
OPRM1	NP_001138751.1	7tmA_Mu_opioid_R	164..442	CDD:320218	86/446 (19%)
		TM helix 1	165..191	CDD:320218	7/25 (28%)
		TM helix 2	198..224	CDD:320218	9/26 (35%)
		TM helix 3	235..265	CDD:320218	9/29 (31%)
		TM helix 4	277..299	CDD:320218	5/25 (20%)
		TM helix 5	324..353	CDD:320218	6/28 (21%)
		TM helix 6	368..398	CDD:320218	12/29 (41%)
		TM helix 7	410..435	CDD:320218	10/27 (37%)