Protein Alignment CCKLR-17D1 and OPRK1

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001305426.1
• Gene: OPRK1 / 4986
• HGNCID: 8154
• Length: 409
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 101/500 - (20%)
• Similarity: 176/500 - (35%)
• Gaps: 196/500 - (39%)

  Fly   146 TTPSSSTLAPAVTVRTPG------NRSV---------VRVSADVPIWVVPCYSAILLCAVVGNLL 195
            |...|:.|.|..:...||      |.|.         ..:|..:|:.:...||.:.:..:|||.|
Human    15 TCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSL 79

  Fly   196 VVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVA 260
            |:..:::..:|:|.||:::.|||::|.|: ...||......|:..:.||::|||::......::.
Human    80 VMFVIIRYTKMKTATNIYIFNLALADALV-TTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMF 143

  Fly   261 VSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIW-LGSLVCMTPIAAFSQLMPTSRPGL 324
            .|.:||..:|.:||.|:|||:::..::|...|..|...|| |.|.|.::.|..          |.
Human   144 TSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVL----------GG 198

  Fly   325 RKCRE---------QWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMN 380
            .|.||         |:|.|..::   ::||:.:.:         |.:.|:...|.:.:
Human   199 TKVREDVDVIECSLQFPDDDYSW---WDLFMKICV---------FIFAFVIPVLIIIV------- 244

  Fly   381 FGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRR 445
                                                                             
Human   245 ----------------------------------------------------------------- 244

  Fly   446 LISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGY 510
                   |      |.:....:||:|         .|||
Human   245 -------C------YTLMILRLKSVR---------LLSG-------------------------- 261

  Fly   511 VSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTML 575
                 ||.|.                      .:.:|:.:::.|:|..|.:||||:::. .:...
Human   262 -----SREKD----------------------RNLRRITRLVLVVVAVFVVCWTPIHIF-ILVEA 298

  Fly   576 LGPTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVD 620
            ||.|.:.....:|..|...|.|::|..|||.|.|::.:|:|.|.|
Human   299 LGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRD 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	89/450 (20%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	8/21 (38%)
		TM helix 3	249..271	CDD:410628	4/21 (19%)
		TM helix 4	294..310	CDD:410628	6/16 (38%)
		TM helix 5	340..363	CDD:410628	3/22 (14%)
		TM helix 6	549..571	CDD:410628	7/21 (33%)
		TM helix 7	586..611	CDD:410628	10/24 (42%)
OPRK1	NP_001305426.1	7tmA_Kappa_opioid_R	60..341	CDD:320219	89/451 (20%)
		TM helix 1	61..87	CDD:320219	7/25 (28%)
		TM helix 2	94..120	CDD:320219	9/26 (35%)
		TM helix 3	131..161	CDD:320219	9/29 (31%)
		TM helix 4	173..195	CDD:320219	7/21 (33%)
		TM helix 5	223..252	CDD:320219	7/122 (6%)
		TM helix 6	267..297	CDD:320219	8/30 (27%)
		TM helix 7	309..334	CDD:320219	10/24 (42%)