Protein Alignment CCKLR-17D1 and OPRD1

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_000902.3
• Gene: OPRD1 / 4985
• HGNCID: 8153
• Length: 372
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 100/498 - (20%)
• Similarity: 173/498 - (34%)
• Gaps: 176/498 - (35%)

  Fly   148 PSSSTLAPAVTVRTPGNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNV 212
            ||:...|.|.....||.||.  .|..:.|.:...|||:....::||:||:..:|:..:|:|.||:
Human    24 PSACPSAGANASGPPGARSA--SSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNI 86

  Fly   213 FLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAI 277
            ::.|||::| .|....:|......|:..:.|||||||.:......::..|.:||..:|.:||.|:
Human    87 YIFNLALAD-ALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAV 150

  Fly   278 CHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTSRPGLRKCREQWPADSLNYERAY 342
            |||:::..::|...|..|...||:.:.....||...:...|  |.|...|..|:|:.|..::...
Human   151 CHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRP--RDGAVVCMLQFPSPSWYWDTVT 213

  Fly   343 NLFLDLALLVLPLLALSFTY-LFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRAN 406
            .:.:.|...|:|:|.::..| |.:.|...|
Human   214 KICVFLFAFVVPILIITVCYGLMLLRLRSV----------------------------------- 243

  Fly   407 GSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLR 471
                                                  ||:||
Human   244 --------------------------------------RLLSG---------------------- 248

  Fly   472 HQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRS 536
                                                        |:.|.
Human   249 --------------------------------------------SKEKD---------------- 253

  Fly   537 NETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGYTSISFLQLLAYSSSC 601
                  .|.:|:.:|:.|:|..|.:||.|:::...:..|:.....:.:...::.....|.|::|.
Human   254 ------RSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSS 312

  Fly   602 CNPITYCFMNASFRRAFVDTFKGMRVCERLCA---PCCFWRRR 641
            .||:.|.|::.:|:|.|      .::|.:.|.   |..|.|.|
Human   313 LNPVLYAFLDENFKRCF------RQLCRKPCGRPDPSSFSRAR 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	83/441 (19%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	7/21 (33%)
		TM helix 3	249..271	CDD:410628	4/21 (19%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	5/23 (22%)
		TM helix 6	549..571	CDD:410628	7/21 (33%)
		TM helix 7	586..611	CDD:410628	7/24 (29%)
OPRD1	NP_000902.3	7tmA_Delta_opioid_R	50..329	CDD:320217	84/442 (19%)
		TM helix 1	51..77	CDD:320217	8/25 (32%)
		TM helix 2	84..110	CDD:320217	8/26 (31%)
		TM helix 3	121..151	CDD:320217	9/29 (31%)
		TM helix 4	163..185	CDD:320217	6/21 (29%)
		TM helix 5	209..239	CDD:320217	6/29 (21%)
		TM helix 6	258..284	CDD:320217	8/25 (32%)
		TM helix 7	297..322	CDD:320217	7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..372		4/10 (40%)