Protein Alignment CCKLR-17D1 and NPY1R

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_000900.1
• Gene: NPY1R / 4886
• HGNCID: 7956
• Length: 384
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 117/511 - (22%)
• Similarity: 185/511 - (36%)
• Gaps: 218/511 - (42%)

  Fly   182 YSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGEL 246
            |.|:::..|.|||.:::.:::.:.||.:||:.::||:.||:|:.:.|:|.|.|.||:.|::|||.
Human    47 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEA 111

  Fly   247 LCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTIN-HANKIIAIIWLGSLVCMTPI 310
            :|||..|.|..|:.||.::||.|:.||:..|.:|   |.|:..| ||...||:||:.::....|.
Human   112 MCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP---RGWRPNNRHAYVGIAVIWVLAVASSLPF 173

  Fly   311 AAFSQLMPTSRP----------GLRKCREQWPADSLNYERAYNLFLDLALLVL----PLLALSFT 361
            ..: |:| |..|          ....|.:|:|:||      :.|.....||||    ||..:...
Human   174 LIY-QVM-TDEPFQNVTLDAYKDKYVCFDQFPSDS------HRLSYTTLLLVLQYFGPLCFIFIC 230

  Fly   362 YLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQ 426
            |.    .:|:.:
Human   231 YF----KIYIRL----------------------------------------------------- 238

  Fly   427 HHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGE 491
                            |||
Human   239 ----------------KRR---------------------------------------------- 241

  Fly   492 CCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLV 556
                 :.|..:|:        ||:                  .||:||      ||:..||..:|
Human   242 -----NNMMDKMR--------DNK------------------YRSSET------KRINIMLLSIV 269

  Fly   557 LEFFICWTPLYVINTMTMLLGPTVYEY----VGYTSISFLQLL----AYSSSCCNPITYCFMNAS 613
            :.|.:||.||.:.|        ||:::    :...:.:.|.||    |..|:|.|||.|.|:|.:
Human   270 VAFAVCWLPLTIFN--------TVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKN 326

  Fly   614 FRR--AFVDTFKGMRVCERLCAPCCFWRRRSKNET------NLSVAGNSIALANSV 661
            |:|  .|...|            |.|..|....||      :..|:..|:..|:.|
Human   327 FQRDLQFFFNF------------CDFRSRDDDYETIAMSTMHTDVSKTSLKQASPV 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	106/460 (23%)
		TM helix 1	178..202	CDD:410628	6/19 (32%)
		TM helix 2	211..233	CDD:410628	8/21 (38%)
		TM helix 3	249..271	CDD:410628	10/21 (48%)
		TM helix 4	294..310	CDD:410628	4/15 (27%)
		TM helix 5	340..363	CDD:410628	7/26 (27%)
		TM helix 6	549..571	CDD:410628	8/21 (38%)
		TM helix 7	586..611	CDD:410628	11/28 (39%)
NPY1R	NP_000900.1	7tmA_NPY1R	41..331	CDD:320517	106/458 (23%)
		TM helix 1	42..68	CDD:320517	6/20 (30%)
		TM helix 2	75..100	CDD:320517	10/24 (42%)
		TM helix 3	113..143	CDD:320517	13/29 (45%)
		TM helix 4	154..175	CDD:320517	7/20 (35%)
		TM helix 5	208..237	CDD:320517	9/32 (28%)
		TM helix 6	256..286	CDD:320517	14/43 (33%)
		TM helix 7	299..324	CDD:320517	11/24 (46%)