Protein Alignment CCKLR-17D1 and RYa-R

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001287552.1
• Gene: RYa-R / 43253
• FlyBaseID: FBgn0004842
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 578
• Identity: 142/578 - (24%)
• Similarity: 197/578 - (34%)
• Gaps: 213/578 - (36%)

  Fly    68 DHKRASFFGLTIDAFYHYLRQALPLAKEAAIHLNASNEISAVGDGVTITGTPGDLLNYSGLELD- 131
            |:.:..:|.....|...|...|||          |.:|.|..|.|.|.|        .|||:.:
  Fly    31 DNYQEGYFIRPDPASLIYNTTALP----------ADDEGSNYGYGSTTT--------LSGLQFET 77

  Fly   132 LGLDLDLNL---DMDLATTPSSSTLAPAVTVRTPGNRSVVRVSADVPIWVVPCYSAILLCAVVGN 193
            ..:.:.:|.   |.||.:....|                   ||...|.|...|..|.:.|::||
  Fly    78 YNITVMMNFSCDDYDLLSEDMWS-------------------SAYFKIIVYMLYIPIFIFALIGN 123

  Fly   194 LLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGT-LLRHFIFGELLCKLIQFAQAA 257
            ..|...:....||||:||.|:.:|||.|||:..||:|.:.:.. :|.::.||..||..:.::||.
  Fly   124 GTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSSFISLFILNYWPFGLALCHFVNYSQAV 188

  Fly   258 SVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTSRP 322
            ||.||::||||||.:||.||..||:.|.  |..:|..|||.:|..:|....||...|.|.....|
  Fly   189 SVLVSAYTLVAISIDRYIAIMWPLKPRI--TKRYATFIIAGVWFIALATALPIPIVSGLDIPMSP 251

  Fly   323 GLRK-----CREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFG 382
            ...|     |||.||:.:..|  .|.|.|.....|:||..|.|||..||..::
  Fly   252 WHTKCEKYICREMWPSRTQEY--YYTLSLFALQFVVPLGVLIFTYARITIRVW------------ 302

  Fly   383 SSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLI 447
                                                                       :||
  Fly   303 -----------------------------------------------------------AKR--- 305

  Fly   448 SGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVS 512
                                                                       ..|...
  Fly   306 -----------------------------------------------------------PPGEAE 311

  Fly   513 DNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLG 577
            .|..:|.:                      .||:::|||:..:|:.|..||.|   .|.:.:||.
  Fly   312 TNRDQRMA----------------------RSKRKMVKMMLTVVIVFTCCWLP---FNILQLLLN 351

  Fly   578 PTVYEY---VGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLC 632
            ...:.:   :.|...:| ..||.|..|.|||.||:|||.||..||.....|....|.|
  Fly   352 DEEFAHWDPLPYVWFAF-HWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLRRWC 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	112/449 (25%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	11/21 (52%)
		TM helix 3	249..271	CDD:410628	11/21 (52%)
		TM helix 4	294..310	CDD:410628	5/15 (33%)
		TM helix 5	340..363	CDD:410628	9/22 (41%)
		TM helix 6	549..571	CDD:410628	8/21 (38%)
		TM helix 7	586..611	CDD:410628	11/24 (46%)
RYa-R	NP_001287552.1	7tmA_PR4-like	106..394	CDD:320514	113/450 (25%)
		TM helix 1	107..133	CDD:320514	7/25 (28%)
		TM helix 2	140..165	CDD:320514	12/24 (50%)
		TM helix 3	179..209	CDD:320514	16/29 (55%)
		TM helix 4	220..241	CDD:320514	8/20 (40%)
		TM helix 5	271..300	CDD:320514	13/30 (43%)
		TM helix 6	320..350	CDD:320514	11/32 (34%)
		TM helix 7	362..387	CDD:320514	11/25 (44%)