Protein Alignment CCKLR-17D1 and sNPF-R

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_524176.1
• Gene: sNPF-R / 40195
• FlyBaseID: FBgn0036934
• Length: 600
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 114/560 - (20%)
• Similarity: 180/560 - (32%)
• Gaps: 253/560 - (45%)

  Fly   146 TTPSSS---TLAPAV-----TVRTPGNRSVV--RVSAD-------------VPIWVVPCYSAILL 187
            ||.|||   :..|.|     ::.:||..|.:  .|:|.             |.|:....|:.:.:
  Fly    11 TTTSSSISTSQLPLVSTTNWSLTSPGTTSAILADVAASDEDRSGGIIHNQFVQIFFYVLYATVFV 75

  Fly   188 CAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQ 252
            ..|.||:||...:::||.|:|:||:|:.|||:|||||.|..:|.|.:.|.:..:.||..||.|:.
  Fly    76 LGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYTFMGRWAFGRSLCHLVS 140

  Fly   253 FAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIA------ 311
            |||..|:.:|:.||.:|:.:||:.|.:|...|  ..::....||..||:.:|:...|..
  Fly   141 FAQGCSIYISTLTLTSIAIDRYFVIIYPFHPR--MKLSTCIGIIVSIWVIALLATVPYGMYMKMT 203

  Fly   312 -------------------------------------------AFSQLMPTSRPGLRK------C 327
                                                       |:.|:|.....|...      |
  Fly   204 NELVNGTQTGNETLVEATLMLNGSFVAQGSGFIEAPDSTSATQAYMQVMTAGSTGPEMPYVRVYC 268

  Fly   328 REQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSS 392
            .|.||::  .|.:.:.........|||...:|..|::|:..|     |:||.
  Fly   269 EENWPSE--QYRKVFGAITTTLQFVLPFFIISICYVWISVKL-----NQRAR------------- 313

  Fly   393 SAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRR 457
                |:.||:
  Fly   314 ----AKPGSK------------------------------------------------------- 319

  Fly   458 HLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLS 522
                                                                     .|||
  Fly   320 ---------------------------------------------------------SSRR---- 323

  Fly   523 QPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVY------ 581
                           |....:.|||..:||..:|..|.:.|.|:.|:|         ::
  Fly   324 ---------------EEADRDRKKRTNRMLIAMVAVFGLSWLPINVVN---------IFDDFDDK 364

  Fly   582 --EYVGYTSISFL-QLLAYSSSCCNPITYCFMNASFRRAF 618
              |:..|....|: ..:|.||:|.||..|.::|.:||:.|
  Fly   365 SNEWRFYILFFFVAHSIAMSSTCYNPFLYAWLNENFRKEF 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	99/504 (20%)
		TM helix 1	178..202	CDD:410628	6/23 (26%)
		TM helix 2	211..233	CDD:410628	12/21 (57%)
		TM helix 3	249..271	CDD:410628	9/21 (43%)
		TM helix 4	294..310	CDD:410628	5/15 (33%)
		TM helix 5	340..363	CDD:410628	4/22 (18%)
		TM helix 6	549..571	CDD:410628	7/21 (33%)
		TM helix 7	586..611	CDD:410628	9/25 (36%)
sNPF-R	NP_524176.1	7tmA_NPYR-like	64..404	CDD:320331	100/505 (20%)
		TM helix 1	65..91	CDD:320331	6/25 (24%)
		TM helix 2	98..123	CDD:320331	14/24 (58%)
		TM helix 3	136..166	CDD:320331	12/29 (41%)
		TM helix 4	177..198	CDD:320331	6/20 (30%)
		TM helix 5	278..307	CDD:320331	6/28 (21%)
		TM helix 6	329..359	CDD:320331	11/38 (29%)
		TM helix 7	372..397	CDD:320331	8/24 (33%)