Protein Alignment CCKLR-17D1 and AstC-R1

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_649040.2
• Gene: AstC-R1 / 40020
• FlyBaseID: FBgn0036790
• Length: 483
• Species: Drosophila melanogaster
• Alignment Length: 564
• Identity: 114/564 - (20%)
• Similarity: 187/564 - (33%)
• Gaps: 231/564 - (40%)

  Fly   139 NLDMDLATT-------PSSSTLAPAVTVRTPGNRSVVRVSADVP--------------IWVVPCY 182
            |.:..|.||       ..|||:.|..::          ...|:|              ::.|..|
  Fly    30 NTNESLYTTELNHRWISGSSTIQPEESL----------YGTDLPTYQHCIATRNSFADLFTVVLY 84

  Fly   183 SAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISD--ILLGVFCMPVTLVGTLLRHFIFGE 245
            ..:.:..:.||.||:..:::..:|:|:||:::||||::|  .|:|:   |..|....:..:.|||
  Fly    85 GFVCIIGLFGNTLVIYVVLRFSKMQTVTNIYILNLAVADECFLIGI---PFLLYTMRICSWRFGE 146

  Fly   246 LLCKLIQFAQAASVAVSSWT----LVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVC 306
            .:||    |...|.:::|:|    |:.:|.:||.|:|||:.|..::|::.|..:.||.|..|.|.
  Fly   147 FMCK----AYMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTLHIAKVVSAIAWSTSAVL 207

  Fly   307 MTPIAAFSQLMPTSRPGLR-KCREQWPADSLNYER-------AYNLFLDLALLVLPL-LALSFTY 362
            |.|:..::..: ....|:. .|...|| |:  |::       .|..||..|   .|| ..|||.|
  Fly   208 MLPVILYASTV-EQEDGINYSCNIMWP-DA--YKKHSGTTFILYTFFLGFA---TPLCFILSFYY 265

  Fly   363 LFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQH 427
            |.|.:             ..|.||:..|.|.
  Fly   266 LVIRK-------------LRSVGPKPGTKSK---------------------------------- 283

  Fly   428 HHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGEC 492
                          .||
  Fly   284 --------------EKR------------------------------------------------ 286

  Fly   493 CSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVL 557
              |.||                                                :|.:::..::.
  Fly   287 --RAHR------------------------------------------------KVTRLVLTVIS 301

  Fly   558 EFFICWTPLYVINTMTMLLGPTVYEYVGYTSISFLQL--LAYSSSCCNPITYCFMNASFRRAFVD 620
            .:.:||.|.::.....:...|...:......:.||.|  |.||:|..|||.|.|::.:||::|..
  Fly   302 VYILCWLPHWISQVALIHSNPAQRDLSRLEILIFLLLGALVYSNSAVNPILYAFLSENFRKSFFK 366

  Fly   621 TFKGMRV----CERLCAPCCFWRRRSKNETNLSVAGNSIALANS 660
            .|..|..    .:....|..|.::.||..      |.|..|..|
  Fly   367 AFTCMNKQDINAQLQLEPSVFTKQGSKKR------GGSKRLLTS 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	93/457 (20%)
		TM helix 1	178..202	CDD:410628	6/23 (26%)
		TM helix 2	211..233	CDD:410628	9/23 (39%)
		TM helix 3	249..271	CDD:410628	6/25 (24%)
		TM helix 4	294..310	CDD:410628	6/15 (40%)
		TM helix 5	340..363	CDD:410628	9/30 (30%)
		TM helix 6	549..571	CDD:410628	3/21 (14%)
		TM helix 7	586..611	CDD:410628	12/26 (46%)
AstC-R1	NP_649040.2	7tmA_AstC_insect	78..364	CDD:320222	93/458 (20%)
		TM helix 1	79..105	CDD:320222	6/25 (24%)
		TM helix 2	112..138	CDD:320222	11/28 (39%)
		TM helix 3	149..179	CDD:320222	11/33 (33%)
		TM helix 4	191..213	CDD:320222	8/21 (38%)
		TM helix 5	241..270	CDD:320222	12/31 (39%)
		TM helix 6	287..317	CDD:320222	7/77 (9%)
		TM helix 7	332..357	CDD:320222	12/24 (50%)