Protein Alignment CCKLR-17D1 and CrzR

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001261755.1
• Gene: CrzR / 39409
• FlyBaseID: FBgn0036278
• Length: 644
• Species: Drosophila melanogaster
• Alignment Length: 576
• Identity: 109/576 - (18%)
• Similarity: 195/576 - (33%)
• Gaps: 232/576 - (40%)

  Fly    90 LPLAKEAAIHLNASNEISAVGDGVT-------ITGTPGDLLNYSGLELDLGLDLDLNL-DMDLAT 146
            ||....|::.|...||:  |.:..|       :.|...:::||:...:|:|:.:..:: ::.::|
  Fly    11 LPSVPSASMDLETENEV--VSNWSTLANFTRLVAGAAPEIVNYTLNMIDVGVGMATDISNLSVST 73

  Fly   147 TP-------SSSTLAPAVTVRTPGNRSVVRVSADVPIWV--------------VPCYSAILLCAV 190
            ||       :||:||     .|........::..||..|              |...:.:.|.::
  Fly    74 TPLPAYAISNSSSLA-----HTNSRHEAPPMAEQVPEHVMDHAPQLSRSGLLKVYVLAVMALFSL 133

  Fly   191 VGNLLVVLTLVQNRRMR-----TITNVF--LLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLC 248
            :||||.:..:.:.|..|     |.:.::  :.:|:|:|:|:..||:...........::..||.|
  Fly   134 LGNLLTIWNIYKTRISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQWLANELTC 198

  Fly   249 KLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHA---NKIIAIIWLGSLVCMTP- 309
            ||::..|..|:.:|::.||.|..:|:.|:.:|::|     :|.|   ::::...::.|||...|
  Fly   199 KLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKS-----LNMAKRCHRLLGGTYILSLVLSLPQ 258

  Fly   310 -----------IAAFSQLMPTSRPGLRKC------REQWPADSLNYERAYNLFLDLALLVLPLLA 357
                       :..|.|           |      ...|      .|:.|..|..:...:|||..
  Fly   259 FFIFHVARGPFVEEFYQ-----------CVTHGFYTADW------QEQMYATFTLVFTFLLPLCI 306

  Fly   358 LSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTI-VPHQH 421
            |..||:...||:                             :.|::...||...:..|. :|.|.
  Fly   307 LFGTYMSTFRTI-----------------------------SSSEKMFQGSKLANYSTAKLPTQT 342

  Fly   422 NPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTG 486
            |                    ::|||               ..|.:||||
  Fly   343 N--------------------RQRLI---------------HKAKMKSLR--------------- 357

  Fly   487 AGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKM 551
                                                                            :
  Fly   358 ----------------------------------------------------------------I 358

  Fly   552 LFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGYTSISFLQLLAYSSSCCNPITY 607
            ..|:::.|.|||||.||:..|.|.|.|.  :.:|......:.....|:|..||:.|
  Fly   359 SVVIIIAFLICWTPYYVMMIMFMFLNPD--KRLGDDLQDAIFFFGMSNSLVNPLIY 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	86/474 (18%)
		TM helix 1	178..202	CDD:410628	7/37 (19%)
		TM helix 2	211..233	CDD:410628	6/23 (26%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	4/27 (15%)
		TM helix 5	340..363	CDD:410628	7/22 (32%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	5/22 (23%)
CrzR	NP_001261755.1	7tmA_GnRHR_invertebrate	119..419	CDD:320506	85/461 (18%)
		TM helix 1	120..146	CDD:320506	6/25 (24%)
		TM helix 2	160..187	CDD:320506	6/26 (23%)
		TM helix 3	198..228	CDD:320506	11/29 (38%)
		TM helix 4	239..260	CDD:320506	4/20 (20%)
		TM helix 5	288..317	CDD:320506	9/28 (32%)
		TM helix 6	350..380	CDD:320506	14/108 (13%)
		TM helix 7	391..416	CDD:320506	5/22 (23%)