Protein Alignment CCKLR-17D1 and Hcrtr2

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_945200.1
• Gene: Hcrtr2 / 387285
• MGIID: 2680765
• Length: 460
• Species: Mus musculus
• Alignment Length: 118
• Identity: 27/118 - (22%)
• Similarity: 47/118 - (39%)
• Gaps: 33/118 - (27%)

  Fly    18 FTFIIYLVSPTTLLNLFYGEFDPYLSAD-RKVVVYEKMIEALRNMDKYCKDRRFYC--------- 72
            ||...||:...|:.|   || .||.... .|...:::.::.  :|..:..::.:.|
Mouse    98 FTRKQYLIEHMTIHN---GE-KPYTCQQCGKSFTWKQNLKI--HMRTHTDEKPYTCHQCGKSFAR 156

  Fly    73 KRPETRHVDCRRVLRGDKAYL-----------QSLTGINRIPLIENPFLNLTC 114
            .:..::|:.   |..|:|.|.           |:|||..|:...|.|:   ||
Mouse   157 NQNLSKHMG---VHTGEKPYTCECCGKCFTRQQNLTGHMRVHTGEKPY---TC 203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119
		TM helix 1	178..202	CDD:410628
		TM helix 2	211..233	CDD:410628
		TM helix 3	249..271	CDD:410628
		TM helix 4	294..310	CDD:410628
		TM helix 5	340..363	CDD:410628
		TM helix 6	549..571	CDD:410628
		TM helix 7	586..611	CDD:410628
Hcrtr2	NP_945200.1	Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43614	33..49
		7tmA_OXR	55..375	CDD:320336	27/118 (23%)
		TM helix 1	56..82	CDD:320336
		TM helix 2	89..115	CDD:320336	8/20 (40%)
		TM helix 3	127..157	CDD:320336	2/31 (6%)
		TM helix 4	168..189	CDD:320336	4/20 (20%)
		TM helix 5	220..249	CDD:320336
		TM helix 6	297..327	CDD:320336
		TM helix 7	343..368	CDD:320336
		Orexin_rec2	386..443	CDD:427531