Protein Alignment CCKLR-17D1 and HCRTR2

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_016866287.1
• Gene: HCRTR2 / 3062
• HGNCID: 4849
• Length: 461
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 123/523 - (23%)
• Similarity: 199/523 - (38%)
• Gaps: 178/523 - (34%)

  Fly   177 WV-VPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRH 240
            || :..|..:.:.|::||:||.:.:.:|..|||:||.|::||:::|:|:.:.|:|.|||..:...
Human    55 WVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITET 119

  Fly   241 FIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLV 305
            :.||:.|||:|.:.|..||:||..||..|:.:|:|||||||..::  |...|...|.|||:.|.:
Human   120 WFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARNSIVIIWIVSCI 182

  Fly   306 CMTPIAAFSQLMPTSRPGLRK-------CREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYL 363
            .|.|.|...: ..|..|||..       |.|:|..:.  |.:.|::...|...:.||..:...||
Human   183 IMIPQAIVME-CSTVFPGLANKTTLFTVCDERWGGEI--YPKMYHICFFLVTYMAPLCLMVLAYL 244

  Fly   364 FITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHH 428
            .|.|.|:                                       |:.
Human   245 QIFRKLW---------------------------------------CRQ---------------- 254

  Fly   429 HHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECC 493
                                                                 :.||.
Human   255 -----------------------------------------------------IPGTS------- 259

  Fly   494 SRVHRMRQQMQ--LQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLV 556
            |.|.|..:.:|  .|.:|.....:||..:::.              |.|.:.::::..:||.:::
Human   260 SVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAA--------------EIKQIRARRKTARMLMIVL 310

  Fly   557 LEFFICWTPLYVINTMTMLLG--------PTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNAS 613
            |.|.||:.|:.::|.:..:.|        .|||.:     .:|...|.|::|..|||.|.|::..
Human   311 LVFAICYLPISILNVLKRVFGMFAHTEDRETVYAW-----FTFSHWLVYANSAANPIIYNFLSGK 370

  Fly   614 FRRAFVDTFKGMRVCERLCAPCC----------FWRRRSKNETNLSVAGNSIALAN-SVMSSHTI 667
            ||..|...|.        |  ||          ..|.|:..|:..|:........| |.:|...:
Human   371 FREEFKAAFS--------C--CCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVV 425

  Fly   668 LES 670
            |.|
Human   426 LTS 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	109/458 (24%)
		TM helix 1	178..202	CDD:410628	7/24 (29%)
		TM helix 2	211..233	CDD:410628	8/21 (38%)
		TM helix 3	249..271	CDD:410628	10/21 (48%)
		TM helix 4	294..310	CDD:410628	6/15 (40%)
		TM helix 5	340..363	CDD:410628	4/22 (18%)
		TM helix 6	549..571	CDD:410628	7/21 (33%)
		TM helix 7	586..611	CDD:410628	9/24 (38%)
HCRTR2	XP_016866287.1	7tmA_OXR	55..375	CDD:320336	109/458 (24%)
		TM helix 1	56..82	CDD:320336	7/25 (28%)
		TM helix 2	89..115	CDD:320336	12/25 (48%)
		TM helix 3	127..157	CDD:320336	14/29 (48%)
		TM helix 4	168..189	CDD:320336	8/20 (40%)
		TM helix 5	220..249	CDD:320336	7/28 (25%)
		TM helix 6	297..327	CDD:320336	8/29 (28%)
		TM helix 7	343..368	CDD:320336	10/29 (34%)
		Orexin_rec2	387..444	CDD:427531	9/42 (21%)