DRSC/TRiP Functional Genomics Resources

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Protein Alignment CCKLR-17D1 and HCRTR1

DIOPT Version :10

Sequence 1:NP_001097021.1 Gene:CCKLR-17D1 / 32860 FlyBaseID:FBgn0259231 Length:673 Species:Drosophila melanogaster
Sequence 2:NP_001516.2 Gene:HCRTR1 / 3061 HGNCID:4848 Length:425 Species:Homo sapiens


Alignment Length:562 Identity:141/562 - (25%)
Similarity:219/562 - (38%) Gaps:176/562 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 MDLATTPSSSTLAPAVTVRTPGNRSVVRVSADVP------IW------------VVPCYSAILLC 188
            |:.:.||.:....|      ||:|....|..|..      :|            ::..|.|:.:.
Human     1 MEPSATPGAQMGVP------PGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVV 59

  Fly   189 AVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQF 253
            |:|||.||.|.:.:|..|||:||.|::||:::|:|:...|:|.:|:..:...::||..|||:|.:
Human    60 ALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPY 124

  Fly   254 AQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAF---SQ 315
            .||.||:|:..||..|:.:|:|||||||..::  |...|...|..||..||..|.|.||.   |.
Human   125 LQAVSVSVAVLTLSFIALDRWYAICHPLLFKS--TARRARGSILGIWAVSLAIMVPQAAVMECSS 187

  Fly   316 LMP--TSRPGL-RKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNER 377
            ::|  .:|..| ..|.|:| ||.| |.:.|:....:...:.||..::..|..|.|.|:       
Human   188 VLPELANRTRLFSVCDERW-ADDL-YPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLW------- 243

  Fly   378 AMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGS 442
                   |.::..::||                     :|.:...|..|                
Human   244 -------GRQIPGTTSA---------------------LVRNWKRPSDQ---------------- 264

  Fly   443 KRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQ 507
                                                                             
Human   265 ----------------------------------------------------------------- 264

  Fly   508 QGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTM 572
               :.|.|.......||..|...|      |.|.:.::::..|||.|::|.|.:|:.|:.|:|.:
Human   265 ---LGDLEQGLSGEPQPRARAFLA------EVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVL 320

  Fly   573 TMLLG----PTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFK----GMRVCE 629
            ..:.|    .:..|.| |...:|...|.|::|..|||.|.|::..||..|...|.    |:..|.
Human   321 KRVFGMFRQASDREAV-YACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCG 384

  Fly   630 RLCAPCCFWRRRSKNETNLSVAGN-SIALANSVMSSHTILES 670
            .|.||.   .|.|.:..:||:... ||    |.:|.|.:|.|
Human   385 SLKAPS---PRSSASHKSLSLQSRCSI----SKISEHVVLTS 419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CCKLR-17D1NP_001097021.1 7tm_GPCRs 177..618 CDD:475119 114/462 (25%)
TM helix 1 178..202 CDD:410628 9/23 (39%)
TM helix 2 211..233 CDD:410628 8/21 (38%)
TM helix 3 249..271 CDD:410628 10/21 (48%)
TM helix 4 294..310 CDD:410628 6/15 (40%)
TM helix 5 340..363 CDD:410628 3/22 (14%)
TM helix 6 549..571 CDD:410628 9/21 (43%)
TM helix 7 586..611 CDD:410628 10/24 (42%)
HCRTR1NP_001516.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 7/28 (25%)
Required for response to orexin-A. /evidence=ECO:0000269|PubMed:26950369 26..41 2/14 (14%)
7tmA_OXR 47..369 CDD:320336 113/451 (25%)
TM helix 1 48..74 CDD:320336 9/25 (36%)
TM helix 2 81..107 CDD:320336 10/25 (40%)
TM helix 3 119..149 CDD:320336 14/29 (48%)
TM helix 4 160..181 CDD:320336 8/20 (40%)
TM helix 5 212..241 CDD:320336 5/28 (18%)
TM helix 6 291..321 CDD:320336 10/29 (34%)
TM helix 7 337..362 CDD:320336 10/24 (42%)

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