Protein Alignment CCKLR-17D1 and ednrba

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_571272.1
• Gene: ednrba / 30442
• ZFINID: ZDB-GENE-980526-16
• Length: 426
• Species: Danio rerio
• Alignment Length: 580
• Identity: 103/580 - (17%)
• Similarity: 184/580 - (31%)
• Gaps: 248/580 - (42%)

  Fly   144 LATTPSSSTLAPAVTVRTPGNRSVVRVSADVPIW----------------VVPCYSAILLCAVVG 192
            |:..|.|.|....:.:....|.|:.|....:|..                ||.|  .:.:..::|
Zfish    38 LSMGPLSPTQKSTIVIGNQINESMPRRPKVLPPMCTDPTEIRDTFKYINTVVSC--LVFVVGIIG 100

  Fly   193 NLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAA 257
            |..::..:.:|:.||...|:.:.:||:.|:|..:..:|:.:...|.:.:.||..||||:.|.|..
Zfish   101 NSTLLRIIYKNKCMRNGPNILIASLALGDLLHIMIDIPINVYKLLAKDWPFGVGLCKLVPFIQKT 165

  Fly   258 SVAVSSWTLVAISCERYYAICHPLRSR-----TWQTINHANKIIAIIWLGSLVCMTPIA-AFSQL 316
            ||.::..:|.|:|.:|:.|:....|.:     .|..|.     |.:||:.|::...|.| ||..:
Zfish   166 SVGITILSLCALSIDRFRAVSSWNRIKGIGVPKWTAIE-----IILIWVLSIILAVPEAIAFDMI 225

  Fly   317 -MPTSRPGLRKCREQWPADSLN----YERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNE 376
             |......||.|... |...:.    |::|.:.:|......:||...:..|..:|
Zfish   226 TMDYKGEQLRICLLH-PKQRIKFMQFYKKAKDWWLFSFYFCMPLTCTAIFYTLMT---------- 279

  Fly   377 RAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCG 441
                                             |:.|
Zfish   280 ---------------------------------CEML---------------------------- 283

  Fly   442 SKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQ 506
                                                                    |.:..:|:.
Zfish   284 --------------------------------------------------------RKKNGVQIA 292

  Fly   507 QQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINT 571
                :||:                           ::.::.|.|.:|.|||.|.:||.||:
Zfish   293 ----LSDH---------------------------IKQRREVAKTVFCLVLVFALCWLPLH---- 322

  Fly   572 MTMLLGPTVY-----------------EYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFV 619
            ::.:|..|:|                 :|:|..       :|..:||.|||....::..|:.
Zfish   323 LSRILQRTIYDERDPNRCELLSFFLVLDYIGIN-------MASVNSCINPIALYMVSKRFKS--- 377

  Fly   620 DTFKGMRVCERLCAPCCFW----------RRRSKNETNLSVAGNSIALANSVMSSHTILE 669
                    |.|.|. || |          .::|..:..::..|::|    :.||..:||:
Zfish   378 --------CFRSCL-CC-WCLPPEILAMDDKQSCIKLKVTERGSAI----TAMSPTSILQ 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	82/484 (17%)
		TM helix 1	178..202	CDD:410628	5/23 (22%)
		TM helix 2	211..233	CDD:410628	6/21 (29%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	4/15 (27%)
		TM helix 5	340..363	CDD:410628	4/22 (18%)
		TM helix 6	549..571	CDD:410628	10/21 (48%)
		TM helix 7	586..611	CDD:410628	6/24 (25%)
ednrba	NP_571272.1	7tmA_ET-BR	84..379	CDD:320642	82/482 (17%)
		TM helix 1	85..111	CDD:320642	5/27 (19%)
		TM helix 2	118..144	CDD:320642	6/25 (24%)
		TM helix 3	156..186	CDD:320642	12/29 (41%)
		TM helix 4	198..218	CDD:320642	6/24 (25%)
		TM helix 5	252..277	CDD:320642	5/24 (21%)
		TM helix 6	298..328	CDD:320642	11/33 (33%)
		TM helix 7	347..372	CDD:320642	8/31 (26%)