Protein Alignment CCKLR-17D1 and Oprk1

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_038965287.1
• Gene: Oprk1 / 29335
• RGDID: 69426
• Length: 431
• Species: Rattus norvegicus
• Alignment Length: 519
• Identity: 106/519 - (20%)
• Similarity: 182/519 - (35%)
• Gaps: 203/519 - (39%)

  Fly   148 PSSSTLAPAVTVRTPGNRSV---------VRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQN 203
            |:||:..|. ...:..|.||         ..:|..:|:.:...||.:.:..:|||.||:..:::.
  Rat    75 PNSSSWFPN-WAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRY 138

  Fly   204 RRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVA 268
            .:|:|.||:::.|||::|.|: ...||......|:..:.||::|||::......::..|.:||..
  Rat   139 TKMKTATNIYIFNLALADALV-TTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTM 202

  Fly   269 ISCERYYAICHPLRSRTWQTINHANKIIAIIW-LGSLVCMTPIAAFSQLMPTSRPGLRKCRE--- 329
            :|.:||.|:|||:::..::|...|..|...|| |.|.|.::.|..          |..|.||
  Rat   203 MSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVL----------GGTKVREDVD 257

  Fly   330 ------QWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEV 388
                  |:|.|..::   ::||:.:.:         |.:.|:...|.:.:
  Rat   258 VIECSLQFPDDEYSW---WDLFMKICV---------FVFAFVIPVLIIIV--------------- 295

  Fly   389 TTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPC 453
                                                                            |
  Rat   296 ----------------------------------------------------------------C 296

  Fly   454 EGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRR 518
                  |.:....:||:|         .|||                               ||.
  Rat   297 ------YTLMILRLKSVR---------LLSG-------------------------------SRE 315

  Fly   519 KSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEY 583
            |.                      .:.:|:.|::.|:|..|.|||||:::. .:...||.|.:..
  Rat   316 KD----------------------RNLRRITKLVLVVVAVFIICWTPIHIF-ILVEALGSTSHST 357

  Fly   584 VGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFWRRRSKNETN 647
            ...:|..|...|.|::|..||:.|.|::.:|:|.|.|          .|.|  ...|..:..||
  Rat   358 AVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRD----------FCFP--IKMRMERQSTN 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	90/450 (20%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	8/21 (38%)
		TM helix 3	249..271	CDD:410628	4/21 (19%)
		TM helix 4	294..310	CDD:410628	6/16 (38%)
		TM helix 5	340..363	CDD:410628	3/22 (14%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	9/24 (38%)
Oprk1	XP_038965287.1	7tmA_Kappa_opioid_R	111..392	CDD:320219	90/451 (20%)
		TM helix 1	112..138	CDD:320219	7/25 (28%)
		TM helix 2	145..171	CDD:320219	9/26 (35%)
		TM helix 3	182..212	CDD:320219	9/29 (31%)
		TM helix 4	224..246	CDD:320219	7/21 (33%)
		TM helix 5	274..303	CDD:320219	7/122 (6%)
		TM helix 6	318..348	CDD:320219	10/30 (33%)
		TM helix 7	360..385	CDD:320219	9/24 (38%)