Protein Alignment CCKLR-17D1 and Oprl1

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001305876.1
• Gene: Oprl1 / 29256
• RGDID: 68438
• Length: 396
• Species: Rattus norvegicus
• Alignment Length: 485
• Identity: 92/485 - (18%)
• Similarity: 161/485 - (33%)
• Gaps: 178/485 - (36%)

  Fly   171 SADVP----IWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPV 231
            ||.:|    :.:|..|.|:.:..::||.||:..::::.:|:|.||:::.|||::|.|: :..:|.
  Rat    40 SAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPF 103

  Fly   232 TLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKII 296
            .....||..:.||..|||.:......::..|::||.|:|.:||.|||||:|:...:|.:.|..:.
  Rat   104 QGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVN 168

  Fly   297 AIIWLGSLVCMTPIAAFSQLMPTSRPGLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFT 361
            ..||..:.|...|:|...........  .:|..:.||....:...:.:.:.|...::|:|.:|..
  Rat   169 VAIWALASVVGVPVAIMGSAQVEDEE--IECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVC 231

  Fly   362 YLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQ 426
            |..:.|.|       |.:
  Rat   232 YSLMIRRL-------RGV----------------------------------------------- 242

  Fly   427 HHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGE 491
                              ||:||
  Rat   243 ------------------RLLSG------------------------------------------ 247

  Fly   492 CCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLV 556
                                    ||.|.                      .:.:|:.:::.|:|
  Rat   248 ------------------------SREKD----------------------RNLRRITRLVLVVV 266

  Fly   557 LEFFICWTPLYVINTMTMLLGPTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDT 621
            ..|..||||:.|. .:...||...........:.|...|.|.:||.|||.|.|::.:|:..|
  Rat   267 AVFVGCWTPVQVF-VLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACF--- 327

  Fly   622 FKGMRVCERLCAPCCFWRRRSKNETNLSVA 651
                   .:.|......|....::...|:|
  Rat   328 -------RKFCCASSLHREMQVSDRVRSIA 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	84/440 (19%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	7/21 (33%)
		TM helix 3	249..271	CDD:410628	5/21 (24%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	4/22 (18%)
		TM helix 6	549..571	CDD:410628	8/21 (38%)
		TM helix 7	586..611	CDD:410628	10/24 (42%)
Oprl1	NP_001305876.1	7tmA_NOFQ_opioid_R	49..327	CDD:320220	84/441 (19%)
		TM helix 1	50..76	CDD:320220	7/25 (28%)
		TM helix 2	83..109	CDD:320220	8/26 (31%)
		TM helix 3	120..150	CDD:320220	10/29 (34%)
		TM helix 4	162..184	CDD:320220	5/21 (24%)
		TM helix 5	209..238	CDD:320220	5/28 (18%)
		TM helix 6	253..283	CDD:320220	9/30 (30%)
		TM helix 7	295..320	CDD:320220	10/24 (42%)