Protein Alignment CCKLR-17D1 and GALR1

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001471.2
• Gene: GALR1 / 2587
• HGNCID: 4132
• Length: 349
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 109/503 - (21%)
• Similarity: 172/503 - (34%)
• Gaps: 191/503 - (37%)

  Fly   128 LELDLGLDLDLNLDMDLATTPSSSTLAPAVTVRTPGNRSVVRVSADVPIWVVPCYSAILLCAVVG 192
            :||.:|     ||....|:.|...  ||     .||....:.|...|.:.|   :..|....|:|
Human     1 MELAVG-----NLSEGNASWPEPP--AP-----EPGPLFGIGVENFVTLVV---FGLIFALGVLG 50

  Fly   193 NLLVVLTLVQNR--RMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQ 255
            |.||:..|.:::  :.|:.||:|:|||:|:|:...:||:|.......|..::.|..:||.|.:..
Human    51 NSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFF 115

  Fly   256 AASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTS 320
            ..|:.||.:||.|:|.:||.||.|..||.:.:...:|...:..||..|:...:|:|....|....
Human   116 TVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPR 180

  Fly   321 RPGLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSG 385
            ......|.||||  ...:::||.:...:...:||||.:.|.|
Human   181 ASNQTFCWEQWP--DPRHKKAYVVCTFVFGYLLPLLLICFCY----------------------- 220

  Fly   386 PEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGG 450
                                                                             
Human   221 ----------------------------------------------------------------- 220

  Fly   451 GPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNE 515
                            .|.|.|                       :|:
Human   221 ----------------AKVLNH-----------------------LHK----------------- 229

  Fly   516 SRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTV 580
             :.|::|:                ||..|||:..:.:.|:|:.|.|.|.|.::|:..      ..
Human   230 -KLKNMSK----------------KSEASKKKTAQTVLVVVVVFGISWLPHHIIHLW------AE 271

  Fly   581 YEYVGYTSISFL-----QLLAYSSSCCNPITYCFMNASFRRAFVDTFK 623
            :.....|..|||     ..||||:|..|||.|.|::.:||:|:...||
Human   272 FGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFK 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	93/447 (21%)
		TM helix 1	178..202	CDD:410628	8/23 (35%)
		TM helix 2	211..233	CDD:410628	10/21 (48%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	7/22 (32%)
		TM helix 6	549..571	CDD:410628	7/21 (33%)
		TM helix 7	586..611	CDD:410628	14/29 (48%)
GALR1	NP_001471.2	7tmA_Gal1_R	34..314	CDD:320226	94/451 (21%)
		TM helix 1	35..61	CDD:320226	9/28 (32%)
		TM helix 2	70..96	CDD:320226	11/25 (44%)
		TM helix 3	108..138	CDD:320226	13/29 (45%)
		TM helix 4	150..170	CDD:320226	4/19 (21%)
		TM helix 5	197..226	CDD:320226	10/132 (8%)
		TM helix 6	240..270	CDD:320226	10/35 (29%)
		TM helix 7	282..307	CDD:320226	12/24 (50%)