DRSC/TRiP Functional Genomics Resources

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Protein Alignment CCKLR-17D1 and Hcrtr2

DIOPT Version :10

Sequence 1:NP_001097021.1 Gene:CCKLR-17D1 / 32860 FlyBaseID:FBgn0259231 Length:673 Species:Drosophila melanogaster
Sequence 2:NP_037206.1 Gene:Hcrtr2 / 25605 RGDID:2788 Length:460 Species:Rattus norvegicus


Alignment Length:521 Identity:125/521 - (23%)
Similarity:197/521 - (37%) Gaps:175/521 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 WV-VPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRH 240
            || :..|..:.:.|::||:||.:.:.:|..|||:||.|::||:::|:|:.:.|:|.|||..:...
  Rat    55 WVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITET 119

  Fly   241 FIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLV 305
            :.||:.|||:|.:.|..||:||..||..|:.:|:|||||||..::  |...|...|.:||:.|.:
  Rat   120 WFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARNSIVVIWIVSCI 182

  Fly   306 CMTPIAAFSQLMPTSRPGLRK-------CREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYL 363
            .|.|.|...: ..:..|||..       |.|:|..:.  |.:.|::...|...:.||..:...||
  Rat   183 IMIPQAIVME-RSSMLPGLANKTTLFTVCDERWGGEV--YPKMYHICFFLVTYMAPLCLMVLAYL 244

  Fly   364 FITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHH 428
            .|.|.|:                                       |:.                
  Rat   245 QIFRKLW---------------------------------------CRQ---------------- 254

  Fly   429 HHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECC 493
                                                                 :.||.       
  Rat   255 -----------------------------------------------------IPGTS------- 259

  Fly   494 SRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLE 558
            |.|.|..:|.|...|        .|.|..|...||:..    :.|.|.:.::::..:||.|::|.
  Rat   260 SVVQRKWKQPQPVSQ--------PRGSGQQSKARISAV----AAEIKQIRARRKTARMLMVVLLV 312

  Fly   559 FFICWTPLYVINTMTMLLG--------PTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFR 615
            |.||:.|:.::|.:..:.|        .|||.:     .:|...|.|::|..|||.|.|::..||
  Rat   313 FAICYLPISILNVLKRVFGMFTHTEDRETVYAW-----FTFSHWLVYANSAANPIIYNFLSGKFR 372

  Fly   616 RAFVDTFKGMRVCERLCAPCCFW----------RRRSKNETNLSVAGNSIALAN-SVMSSHTILE 669
            ..|...|.           ||..          |.|:..|:..|:........| |.:|.|..|.
  Rat   373 EEFKAAFS-----------CCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALT 426

  Fly   670 S 670
            |
  Rat   427 S 427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CCKLR-17D1NP_001097021.1 7tm_GPCRs 177..618 CDD:475119 111/456 (24%)
TM helix 1 178..202 CDD:410628 7/24 (29%)
TM helix 2 211..233 CDD:410628 8/21 (38%)
TM helix 3 249..271 CDD:410628 10/21 (48%)
TM helix 4 294..310 CDD:410628 5/15 (33%)
TM helix 5 340..363 CDD:410628 4/22 (18%)
TM helix 6 549..571 CDD:410628 8/21 (38%)
TM helix 7 586..611 CDD:410628 9/24 (38%)
Hcrtr2NP_037206.1 Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43614 33..49
7tmA_OXR 55..375 CDD:320336 111/456 (24%)
TM helix 1 56..82 CDD:320336 7/25 (28%)
TM helix 2 89..115 CDD:320336 12/25 (48%)
TM helix 3 127..157 CDD:320336 14/29 (48%)
TM helix 4 168..189 CDD:320336 7/20 (35%)
TM helix 5 220..249 CDD:320336 7/28 (25%)
TM helix 6 297..327 CDD:320336 9/29 (31%)
TM helix 7 343..368 CDD:320336 10/29 (34%)
Orexin_rec2 386..443 CDD:427531 10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

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