Protein Alignment CCKLR-17D1 and Grpr

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_036838.2
• Gene: Grpr / 24938
• RGDID: 2750
• Length: 384
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 111/505 - (21%)
• Similarity: 172/505 - (34%)
• Gaps: 194/505 - (38%)

  Fly   176 IWVVPC-YSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLR 239
            |:|:|. |..|::..::||:.::......:.||.:.|:|:.:||:.|:||.|.|.||.....|..
  Rat    41 IYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLAD 105

  Fly   240 HFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKII----AIIW 300
            .::||.:.||||.|.|..||.||.:||.|:|.:||.||..|:..:.    :||...|    |:||
  Rat   106 RWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQA----SHALMKICLKAALIW 166

  Fly   301 LGSLVCMTPIAAFSQLMP-----TSRPGLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSF 360
            :.|::...|.|.||.|.|     |::..: .| ..:|..:..:.:.:::...|...::||..:|.
  Rat   167 IVSMLLAIPEAVFSDLHPFHVKDTNQTFI-SC-APYPHSNELHPKIHSMASFLVFYIIPLSIISV 229

  Fly   361 TYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQ 425
            .|.||.|.|..|..|.
  Rat   230 YYYFIARNLIQSAYNL------------------------------------------------- 245

  Fly   426 QHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNG 490
                                      |.||..|:
  Rat   246 --------------------------PVEGNIHV------------------------------- 253

  Fly   491 ECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVL 555
                                                            .|.:||:||:.|.:.|.
  Rat   254 ------------------------------------------------KKQIESRKRLAKTVLVF 270

  Fly   556 VLEFFICWTPLYVINTMTMLLGPTVYEYVGYTSISFL-----QLLAYSSSCCNPITYCFMNASFR 615
            |..|..||.|.:||    .|.....|..|..:.:.|:     :|||:::||.||.....::.|||
  Rat   271 VGLFAFCWLPNHVI----YLYRSYHYSEVDTSMLHFITSICARLLAFTNSCVNPFALYLLSKSFR 331

  Fly   616 RAFVDTFKGMRVCERLCAPCCFWRRRSKNETNLSVAGNSIALANSVMSSH 665
            :    .|....:|   |.|....|..|        .|.|.....|..|::
  Rat   332 K----QFNTQLLC---CQPSLLNRSHS--------TGRSTTCMTSFKSTN 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	100/455 (22%)
		TM helix 1	178..202	CDD:410628	6/24 (25%)
		TM helix 2	211..233	CDD:410628	11/21 (52%)
		TM helix 3	249..271	CDD:410628	12/21 (57%)
		TM helix 4	294..310	CDD:410628	5/19 (26%)
		TM helix 5	340..363	CDD:410628	4/22 (18%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	8/29 (28%)
Grpr	NP_036838.2	7tmA_GRPR	42..334	CDD:320252	100/459 (22%)
		TM helix 1	43..69	CDD:320252	6/25 (24%)
		TM helix 2	76..102	CDD:320252	11/25 (44%)
		TM helix 3	114..144	CDD:320252	17/29 (59%)
		TM helix 4	156..176	CDD:320252	5/19 (26%)
		TM helix 5	208..233	CDD:320252	5/24 (21%)
		TM helix 6	258..288	CDD:320252	14/33 (42%)
		TM helix 7	302..327	CDD:320252	8/24 (33%)