Protein Alignment CCKLR-17D1 and Npffr1

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001170982.1
• Gene: Npffr1 / 237362
• MGIID: 2685082
• Length: 432
• Species: Mus musculus
• Alignment Length: 514
• Identity: 124/514 - (24%)
• Similarity: 176/514 - (34%)
• Gaps: 212/514 - (41%)

  Fly   149 SSSTLAPAVTVRTPGNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVF 213
            |.:..||..::..   .|..:.|:.|....:..|:.|.|..:|||.||...:::||.|||:||:|
Mouse    20 SDAETAPVASLTF---SSYYQHSSPVAAMFIAAYALIFLLCMVGNTLVCFIVLKNRHMRTVTNMF 81

  Fly   214 LLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAIC 278
            :||||:||:|:|:||||.|||..|:..:.|....||:....|..||:.|.:|||||:.||:..|.
Mouse    82 ILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIV 146

  Fly   279 HPLRSRTWQTINHANKIIAIIWLGSLVCMTPIA---------------AFSQLMPTSRPGLRKCR 328
            ||.|.:.  |:..|...||:||..:|:.|.|.|               |.::..|     |..|.
Mouse   147 HPFREKL--TLRKALLTIAVIWALALLIMCPSAVTLTVTREEHHFMLDARNRSYP-----LYSCW 204

  Fly   329 EQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSS 393
            |.||...:  .:.|...|...:.:.||..:...|..|.|.|             ...|.....:.
Mouse   205 EAWPEKGM--RKVYTAVLFAHIYLAPLALIVVMYARIARKL-------------CQAPGPARDAE 254

  Fly   394 AAVAEAG--SQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGR 456
            .||||.|  |:|||
Mouse   255 EAVAEGGRASRRRA--------------------------------------------------- 268

  Fly   457 RHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSL 521
                                                                             
Mouse   269 ----------------------------------------------------------------- 268

  Fly   522 SQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGY 586
                                     |||.||.::.|.|.:.|.||:|:    :||       :.|
Mouse   269 -------------------------RVVHMLVMVALFFTLSWLPLWVL----LLL-------IDY 297

  Fly   587 TSISFLQL-------------LAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLC 632
            ..:|.|||             ||:..|..|||.|.:.|.:|||.|...|:.     :||
Mouse   298 GELSELQLHLLSVYAFPLAHWLAFFHSSANPIIYGYFNENFRRGFQAAFRA-----QLC 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	114/470 (24%)
		TM helix 1	178..202	CDD:410628	8/23 (35%)
		TM helix 2	211..233	CDD:410628	14/21 (67%)
		TM helix 3	249..271	CDD:410628	10/21 (48%)
		TM helix 4	294..310	CDD:410628	6/15 (40%)
		TM helix 5	340..363	CDD:410628	4/22 (18%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	12/37 (32%)
Npffr1	NP_001170982.1	7tm_GPCRs	44..342	CDD:475119	114/471 (24%)
		TM helix 1	46..70	CDD:410628	8/23 (35%)
		TM helix 2	79..101	CDD:410628	14/21 (67%)
		TM helix 3	117..139	CDD:410628	10/21 (48%)
		TM helix 4	160..176	CDD:410628	6/15 (40%)
		TM helix 5	214..237	CDD:410628	4/22 (18%)
		TM helix 6	271..293	CDD:410628	9/25 (36%)
		TM helix 7	310..335	CDD:410628	7/24 (29%)