Protein Alignment CCKLR-17D1 and tkr-1

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_499064.2
• Gene: tkr-1 / 192055
• WormBaseID: WBGene00006576
• Length: 406
• Species: Caenorhabditis elegans
• Alignment Length: 491
• Identity: 94/491 - (19%)
• Similarity: 155/491 - (31%)
• Gaps: 216/491 - (43%)

  Fly   169 RVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTL 233
            |.|....::|...:..::..|::||.:|:..:.|::.|....|.||.|:|.:|:|:.:|.:..:.
 Worm    37 RESLATQVFVAIAFVLLMATAIIGNSVVMWIIYQHKVMHYGFNYFLFNMAFADLLIALFNVGTSW 101

  Fly   234 VGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIA- 297
            ...|...:.:|: ||.|..|...|...||..:::|:|.:|..|:.:||:.|   .::....:||
 Worm   102 TYNLYYDWWYGD-LCTLTSFFGIAPTTVSVCSMMALSWDRCQAVVNPLQKR---PLSRKRSVIAI 162

  Fly   298 -IIWLGSLVCMTPIAAFSQLMPTSRPGLRKCREQWPADSLNYERAY-----------------NL 344
             |||:.|.|...|.|.                    |.|:|....|                 |.
 Worm   163 LIIWVVSTVTALPFAI--------------------AASVNSLYTYDVVTSTVSKAHVCSAPVNT 207

  Fly   345 FLDLALL----VLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRA 405
            |.:..|.    .||::.|..|:..|                             |||
 Worm   208 FFEKVLFGIQYALPIIILGSTFTRI-----------------------------AVA-------- 235

  Fly   406 NGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSL 470
                                                                             
 Worm   236 ----------------------------------------------------------------- 235

  Fly   471 RHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRR 535
                                                   :.:.||:...||             :
 Worm   236 ---------------------------------------FRATNEATDSSL-------------K 248

  Fly   536 SNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGYTSISFLQLLAY--- 597
            :|.|:   :|.:.|||||::|:.|.:||.|.::.:...:      .|:.......:..||.|
 Worm   249 NNHTR---AKSKAVKMLFLMVVAFVVCWLPYHIYHAFAL------EEFFDAARGKYAYLLIYWIA 304

  Fly   598 SSSCC-NPITYCFMNASFRRAFVDTFKGMRV--CER 630
            .|||. |||.|||.|..||..|...|:.:.|  |::
 Worm   305 MSSCAYNPIIYCFANERFRIGFRYVFRWIPVIDCKK 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	88/467 (19%)
		TM helix 1	178..202	CDD:410628	5/23 (22%)
		TM helix 2	211..233	CDD:410628	8/21 (38%)
		TM helix 3	249..271	CDD:410628	6/21 (29%)
		TM helix 4	294..310	CDD:410628	7/17 (41%)
		TM helix 5	340..363	CDD:410628	8/43 (19%)
		TM helix 6	549..571	CDD:410628	10/21 (48%)
		TM helix 7	586..611	CDD:410628	12/28 (43%)
tkr-1	NP_499064.2	7tm_GPCRs	44..326	CDD:475119	88/468 (19%)
		TM helix 1	46..70	CDD:320512	5/23 (22%)
		TM helix 2	79..101	CDD:320512	8/21 (38%)
		TM helix 3	116..138	CDD:320512	6/21 (29%)
		TM helix 4	160..176	CDD:320512	7/15 (47%)
		TM helix 5	207..230	CDD:320512	6/22 (27%)
		TM helix 6	259..281	CDD:320512	10/21 (48%)
		TM helix 7	294..319	CDD:320512	12/24 (50%)