Protein Alignment CCKLR-17D1 and npr-9

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001361821.1
• Gene: npr-9 / 191320
• WormBaseID: WBGene00013974
• Length: 431
• Species: Caenorhabditis elegans
• Alignment Length: 507
• Identity: 115/507 - (22%)
• Similarity: 186/507 - (36%)
• Gaps: 164/507 - (32%)

  Fly   178 VVP-CYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHF 241
            ::| .::.|:|..:|||.|||: :...|:||..||..::.|||||::..:.|:|.|.|......:
 Worm    31 IIPTIFAVIILVGLVGNALVVI-VAFGRQMRNSTNTLIIGLAISDLMFLLLCVPFTAVDYAAPTW 94

  Fly   242 IFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVC 306
            ||.|..|.:|.|.|..|...|.|||..::.:||.|:.:|:.|.|.:|  ..|.:||:       |
 Worm    95 IFPEWTCSMINFFQHTSAYCSVWTLTLMALDRYLAVVYPVESMTLRT--PRNTVIAL-------C 150

  Fly   307 MTPIAAFSQLMPTSR-PGLRKCREQWPADSLNYERAYNLFLDLALL-VLPLLALSFTYLFITRTL 369
            ...|...:..:|..| .|:      :..|.:..:|:....|.:|.. ..|.:|         ||.
 Worm   151 FIYIIIIASQIPVGRMHGI------YVYDFIMEKRSTCAILTIATAEATPTMA---------RTY 200

  Fly   370 YVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYY 434
            :        |.|...|..:....|..:
 Worm   201 F--------MTFNVFGYVLPLGISVVL-------------------------------------- 219

  Fly   435 YDYGHCGSKRRLISGGGPCEGRRHLYCM-RSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHR 498
              ||..               .|.|:.| |..:.:|:       ||..|:...:|
 Worm   220 --YGLM---------------LRKLWDMPRPGNSQSV-------GGRNLTNRDSG---------- 250

  Fly   499 MRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICW 563
                                            :.:||..|..:  :|::|.:::..:::.:.:||
 Worm   251 --------------------------------SSIRRRPEATA--AKRKVTRLVLCVLITWALCW 281

  Fly   564 TPLYVINTMTMLLGP--------TVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVD 620
            .||.|...|:.|..|        .:...|...|    |:|||::||.|||.|..|:.|||..|:.
 Worm   282 LPLNVCFFMSGLAYPEPLVISHGVIMVIVQIAS----QVLAYTNSCLNPILYALMSQSFREGFIR 342

  Fly   621 TFKGMRVCERLCAPCCFWRRRSK--------NETNLSVAGNSIALANSVMSS 664
            ..| |.:.:......|...|||.        |:|....|...:.::|...||
 Worm   343 VMK-MLINKLSRGRFCTNYRRSALRTELTHYNQTPAHPANTVVQVSNGERSS 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	102/451 (23%)
		TM helix 1	178..202	CDD:410628	9/24 (38%)
		TM helix 2	211..233	CDD:410628	8/21 (38%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	5/23 (22%)
		TM helix 6	549..571	CDD:410628	5/21 (24%)
		TM helix 7	586..611	CDD:410628	11/24 (46%)
npr-9	NP_001361821.1	7tmA_AstA_R_insect	30..340	CDD:320224	102/451 (23%)
		TM helix 1	31..57	CDD:320224	9/26 (35%)
		TM helix 2	63..89	CDD:320224	11/25 (44%)
		TM helix 3	101..131	CDD:320224	12/29 (41%)
		TM helix 4	143..163	CDD:320224	5/26 (19%)
		TM helix 5	197..226	CDD:320224	9/100 (9%)
		TM helix 6	261..291	CDD:320224	7/31 (23%)
		TM helix 7	308..333	CDD:320224	12/28 (43%)