Protein Alignment CCKLR-17D1 and EDNRB

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001188326.1
• Gene: EDNRB / 1910
• HGNCID: 3180
• Length: 532
• Species: Homo sapiens
• Alignment Length: 658
• Identity: 128/658 - (19%)
• Similarity: 203/658 - (30%)
• Gaps: 268/658 - (40%)

  Fly    25 GTRTPYGCADTQSRPKPNFLLREVDEVCCTAASASPRLLVLFRDHKRASFFGLTIDAFYHYLRQA 89
            |.|||.| |.:..:|.|:...|.:  |....|....|:....|        |...|       :|
Human    80 GHRTPSG-AGSSMQPPPSLCGRAL--VALVLACGLSRIWGEER--------GFPPD-------RA 126

  Fly    90 LPLAKEAAIHLNASNEISAVGDGVTITGTPGDLLNYSGLELDLGLDLDLNLDMDLATTPSSSTLA 154
            .||.:.|.|....:..:...|...::                                  :.:||
Human   127 TPLLQTAEIMTPPTKTLWPKGSNASL----------------------------------ARSLA 157

  Fly   155 PAVTV---RTPGN--RSVVRVSADVPI----------WVVPCYSAILLCAVVGNLLVVLTLVQNR 204
            ||...   ||.|:  |::.......||          .||.|  .:.:..::||..::..:.:|:
Human   158 PAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSC--LVFVLGIIGNSTLLRIIYKNK 220

  Fly   205 RMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAI 269
            .||...|:.:.:||:.|:|..|..:|:.:...|...:.||..:|||:.|.|.|||.::..:|.|:
Human   221 CMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCAL 285

  Fly   270 SCERYYAICHPLRSR-----TWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTSRPG--LRKC 327
            |.:||.|:....|.:     .|..:.     |.:||:.|:|...|.|....::.....|  ||.|
Human   286 SIDRYRAVASWSRIKGIGVPKWTAVE-----IVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRIC 345

  Fly   328 ---REQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVT 389
               ..|..|....|:.|.:.:|......|||...:|.|..:|
Human   346 LLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMT----------------------- 387

  Fly   390 TSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCE 454
                                |:.|
Human   388 --------------------CEML----------------------------------------- 391

  Fly   455 GRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRK 519
                                                                          |:|
Human   392 --------------------------------------------------------------RKK 394

  Fly   520 SLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLL----GPTV 580
            |..|.:|            ...|:.::.|.|.:|.|||.|.:||.||::...:.:.|    .|..
Human   395 SGMQIAL------------NDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNR 447

  Fly   581 YEYVGYTSISFLQLLAY-------SSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPC-CF 637
            .|.     :|||.:|.|       .:||.|||....::..|:..|       :.|  ||..| .|
Human   448 CEL-----LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCF-------KSC--LCCWCQSF 498

  Fly   638 WRRRSKNE 645
            ..::|..|
Human   499 EEKQSLEE 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	89/461 (19%)
		TM helix 1	178..202	CDD:410628	5/23 (22%)
		TM helix 2	211..233	CDD:410628	7/21 (33%)
		TM helix 3	249..271	CDD:410628	9/21 (43%)
		TM helix 4	294..310	CDD:410628	5/15 (33%)
		TM helix 5	340..363	CDD:410628	6/22 (27%)
		TM helix 6	549..571	CDD:410628	10/21 (48%)
		TM helix 7	586..611	CDD:410628	10/31 (32%)
EDNRB	NP_001188326.1	7tmA_ET-BR	192..487	CDD:320642	89/464 (19%)
		TM helix 1	193..219	CDD:320642	5/27 (19%)
		TM helix 2	226..252	CDD:320642	7/25 (28%)
		TM helix 3	264..294	CDD:320642	14/29 (48%)
		TM helix 4	306..326	CDD:320642	6/24 (25%)
		TM helix 5	360..385	CDD:320642	7/24 (29%)
		TM helix 6	406..436	CDD:320642	11/29 (38%)
		TM helix 7	455..480	CDD:320642	7/24 (29%)