Protein Alignment CCKLR-17D1 and npr-22

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001023541.1
• Gene: npr-22 / 190424
• WormBaseID: WBGene00022004
• Length: 434
• Species: Caenorhabditis elegans
• Alignment Length: 503
• Identity: 116/503 - (23%)
• Similarity: 180/503 - (35%)
• Gaps: 170/503 - (33%)

  Fly   130 LDLGLDLDLNLDMDLATTPSSSTLA-PAVTVRTPGNRSVVRVSADVPIWVVPC---YSAILLCAV 190
            :|.|..:..:|...:.||.|...:. ...|...|..:.:..:....|...:.|   ||.:.:|.|
 Worm     1 MDEGGGIGSSLLSRITTTASEIMMRNEPTTTENPAVQEMNHIYHLTPSMKMLCILFYSILCVCCV 65

  Fly   191 VGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLL---RHFIFGELLCKLIQ 252
            .||:||:|.:|..:|:||.||:.:||||::|:|:.|||:|.:....|:   :.::||.::|.|:.
 Worm    66 YGNVLVILVIVYFKRLRTATNILILNLAVADLLISVFCIPFSYWQVLIYDDQRWLFGSMMCSLLA 130

  Fly   253 FAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLM 317
            |.||.:|.:|:||||.||.:|:.||...|......|...|..::|..|:.|::...|: .|:...
 Worm   131 FLQAMAVFLSAWTLVVISFDRWMAIMFLLTPNIRITRRRALYLVAATWIFSILMALPL-LFTTRF 194

  Fly   318 PTSRPGLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFG 382
            ...:.||..|.|.|                             ||                  ||
 Worm   195 FEDQDGLPNCGENW-----------------------------TY------------------FG 212

  Fly   383 SSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLI 447
            .||.:|              |:...|....|..:||           .:.....|.|.|.|
 Worm   213 DSGEQV--------------RKVYSSMVLILQYVVP-----------QAVLIITYTHIGIK---- 248

  Fly   448 SGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVS 512
                          |.::.|..::    ||.
 Worm   249 --------------MWNSRVPGMQ----NGA---------------------------------- 261

  Fly   513 DNESRRKSLSQPSLRITEAGLRRSNETKSL-----ESKKRVVKMLFVLVLEFFICWTPLYVINTM 572
                                      ||.:     ||.|::|.|:.::...|.:||.||.::..:
 Worm   262 --------------------------TKKMIVDRHESVKKLVPMVILISALFALCWLPLLILINV 300

  Fly   573 TMLLGPTVYEYVGYTSIS--FLQLLAYSSSCCNPITYCFMNASFRRAF 618
            .....|.:..: ||....  |...||.|.|..|||.|...||.||..|
 Worm   301 IPEFYPDINSW-GYILYLWWFAHGLAMSHSMVNPIIYFIRNARFREGF 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	106/453 (23%)
		TM helix 1	178..202	CDD:410628	10/26 (38%)
		TM helix 2	211..233	CDD:410628	11/21 (52%)
		TM helix 3	249..271	CDD:410628	11/21 (52%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	1/22 (5%)
		TM helix 6	549..571	CDD:410628	7/21 (33%)
		TM helix 7	586..611	CDD:410628	10/26 (38%)
npr-22	NP_001023541.1	7tmA_PR4-like	51..347	CDD:320514	106/451 (24%)
		TM helix 1	52..78	CDD:320514	11/25 (44%)
		TM helix 2	85..110	CDD:320514	12/24 (50%)
		TM helix 3	126..156	CDD:320514	15/29 (52%)
		TM helix 4	169..190	CDD:320514	5/21 (24%)
		TM helix 5	219..248	CDD:320514	8/39 (21%)
		TM helix 6	271..301	CDD:320514	10/29 (34%)
		TM helix 7	315..340	CDD:320514	9/24 (38%)