Protein Alignment CCKLR-17D1 and npr-14

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001379223.1
• Gene: npr-14 / 189211
• WormBaseID: WBGene00012275
• Length: 425
• Species: Caenorhabditis elegans
• Alignment Length: 539
• Identity: 119/539 - (22%)
• Similarity: 189/539 - (35%)
• Gaps: 224/539 - (41%)

  Fly   177 WVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHF 241
            |.|...:::::..|:||.|||:.:..|:.||...|:.|:||||:|:|:.:||:|:|:|..:.:.|
 Worm    48 WFVYILASMMVIGVIGNTLVVVVVATNKSMRNALNLVLMNLAIADLLILLFCLPLTVVNDVTKTF 112

  Fly   242 IFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVC 306
            .|..:.||.:.|....||.||..:||.|:|||:.||.:||:|...:|    ..:|..||..::..
 Worm   113 WFSAVFCKSVNFVNNTSVYVSIMSLVFITCERWRAITYPLKSPFVRT----RSVIGGIWFIAMFL 173

  Fly   307 MTPIAAFSQL--MPTSRPGL-----RKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLF 364
            .:|......|  .|..||..     .:|:|.|   |..:::.|.|...:...|||||.:|...|.
 Worm   174 SSPEPVTLHLAGAPFVRPNFTTKWGTRCKESW---SEEFQKNYQLLQTIFSFVLPLLVISILCLH 235

  Fly   365 ITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHH 429
            :.|||:.
 Worm   236 MVRTLHF---------------------------------------------------------- 242

  Fly   430 HSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCS 494
                                              ||:..::.::||
 Worm   243 ----------------------------------SANYLTVANRQI------------------- 254

  Fly   495 RVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEF 559
                                          |:|                  |:.|:||..:|..|
 Worm   255 ------------------------------SIR------------------KKAVRMLCAVVFLF 271

  Fly   560 FICWTPLYVINTMTM--LLGPTVYEYVGYTSISFLQLL----AYSSSCCNPITYCFMNASFRRAF 618
            .:...|:::.|....  ||...    |...:|:..:||    :|||||.|||.|.|::..||..|
 Worm   272 SMSNLPVHLYNIALNYDLLSTD----VSTNTIAVRKLLPRVFSYSSSCLNPILYSFLSGRFREEF 332

  Fly   619 VDTFKGMRVCERLCAPCCF--------WRRRSKN--------------------ETNLSVAGNSI 655
                 |..|       ||.        :||:..:                    ||..|:....:
 Worm   333 -----GRVV-------CCLRDEKSSREFRRKQASLYASSQRVRTNSCSTMLLDRETRSSLIIRRV 385

  Fly   656 ALANSVMSSHTIL-ESPRL 673
            :||.::.||..|. ::|||
 Worm   386 SLAQAIPSSPLIAHQNPRL 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	101/453 (22%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	11/21 (52%)
		TM helix 3	249..271	CDD:410628	9/21 (43%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	8/22 (36%)
		TM helix 6	549..571	CDD:410628	6/21 (29%)
		TM helix 7	586..611	CDD:410628	13/28 (46%)
npr-14	NP_001379223.1	7tmA_CCKR-like	48..332	CDD:320124	101/453 (22%)
		TM helix 1	48..74	CDD:320124	8/25 (32%)
		TM helix 2	81..107	CDD:320124	13/25 (52%)
		TM helix 3	119..149	CDD:320124	14/29 (48%)
		TM helix 4	159..177	CDD:320124	4/21 (19%)
		TM helix 5	210..235	CDD:320124	8/24 (33%)
		TM helix 6	255..285	CDD:320124	10/47 (21%)
		TM helix 7	300..325	CDD:320124	12/24 (50%)