Protein Alignment CCKLR-17D1 and ckr-1

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_491918.3
• Gene: ckr-1 / 188774
• WormBaseID: WBGene00020712
• Length: 421
• Species: Caenorhabditis elegans
• Alignment Length: 452
• Identity: 129/452 - (28%)
• Similarity: 197/452 - (43%)
• Gaps: 116/452 - (25%)

  Fly   183 SAILLC---AVVGNLLVVLTLV-QNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIF 243
            |..|||   :::||.:|:||:: ::.|.|:|||.:|||||.:|:|..:.|:|.||:|.|.:.::.
 Worm    18 SIFLLCLILSLLGNAIVILTILGKSHRSRSITNFYLLNLAFADLLRSIICIPSTLLGELTQCWLL 82

  Fly   244 GELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMT 308
            |..:||::.|.|...|..|::||..|:.|||||||.||.||.|||...|...|:::|     |.:
 Worm    83 GAAMCKIVAFLQPVGVCASAYTLAVIAIERYYAICRPLESRKWQTKKRALITISLVW-----CFS 142

  Fly   309 PIAAFSQL-MPTSRPGLRKCREQWPADSLN---YERAYNLFLDLALLVLPLLALSFTYLFITRTL 369
            ..|..:.| :..:.||...|      ||..   .:..|.|:|...||.:||
 Worm   143 FSANLTSLFLYDANPGKFTC------DSTKGPLVDFIYQLYLTFTLLFVPL-------------- 187

  Fly   370 YVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSH----CQSLDTIVPHQHNPHQQHHHH 430
                    |:..|..|..:.|.::|          .|..|    .|.::..:|
 Worm   188 --------ALMVGLYGNVIITLNTA----------INSDHPTVEQQMIEKTLP------------ 222

  Fly   431 SQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSR 495
            |:..:......:.:|:.|             |:..| |:.:.::.|
 Worm   223 SRASFSDWFVSAVQRVPS-------------MKVVS-KTFQFKEKN------------------- 254

  Fly   496 VHRMRQQMQLQQQGYVSDNESRRK-----SLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVL 555
                  .:.:.|...:|...||..     |..:.|..:|.. ||.:|:.|.|.:||:|.:||..|
 Worm   255 ------SLSIPQTSGLSVRPSRSSFSSFFSTPRGSFDVTML-LRSTNQEKILIAKKKVTRMLITL 312

  Fly   556 VLEFFICWTPLYVINTMTML--LGPTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFR 615
            |:.|..||.|.|:...:..:  |..|.....|..  |.|.::.|.||..|||||||||.|||
 Worm   313 VIVFAFCWVPSYLYWLLLRMAELAATDLWNPGLN--SSLTIMTYISSLANPITYCFMNKSFR 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	129/452 (29%)
		TM helix 1	178..202	CDD:410628	9/22 (41%)
		TM helix 2	211..233	CDD:410628	10/21 (48%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	7/22 (32%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	12/24 (50%)
ckr-1	NP_491918.3	7tmA_CCKR-like	30..375	CDD:320124	125/440 (28%)
		TM helix 2	49..75	CDD:320124	13/25 (52%)
		TM helix 3	87..117	CDD:320124	14/29 (48%)
		TM helix 4	131..149	CDD:320124	5/22 (23%)
		TM helix 5	171..196	CDD:320124	9/46 (20%)
		TM helix 6	300..330	CDD:320124	12/29 (41%)
		TM helix 7	343..368	CDD:320124	13/26 (50%)