Protein Alignment CCKLR-17D1 and npr-6

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_509725.2
• Gene: npr-6 / 185623
• WormBaseID: WBGene00009619
• Length: 402
• Species: Caenorhabditis elegans
• Alignment Length: 518
• Identity: 113/518 - (21%)
• Similarity: 181/518 - (34%)
• Gaps: 213/518 - (41%)

  Fly   150 SSTLAPAVT----VRTPGNRSVVRVSADVPI-------WVVPCYSAILLCAVVGNLLVVLTLVQN 203
            |:.|.|:|:    ..||..:|..::..: |:       :.:..|.|:.|.|..||.|||..::.|
 Worm     2 SNDLVPSVSSILNETTPSYQSTCKIKNN-PMEMEYFRPFFISMYCAVFLVASSGNFLVVYVVMTN 65

  Fly   204 RRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVA 268
            :||:||||:|:.|||:|||::....:.:|...|.:.|:|||..||..:...|..|:.:|:|||.|
 Worm    66 KRMQTITNIFITNLAVSDIMVNFTSLWLTPTYTSIGHWIFGGGLCHGLPLFQGTSIFISTWTLTA 130

  Fly   269 ISCERYYAICHPLRSRTWQTINHAN-------------KIIAIIWLGSLVCMTPIAAFSQLMPTS 320
            |:.:||..|.|          |.:|             ..|.:|||.||:.:||.|...:|....
 Worm   131 IAIDRYIVIVH----------NSSNININDRMSMRSCLSFIVLIWLCSLLLVTPYAINMKLNYIH 185

  Fly   321 RP-GLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSS 384
            .| ....|.|.|  .:..:...:.:.:.:...:||.:.::.:|:.|  .|:::.|
 Worm   186 EPCDFLICSEDW--SNAEFRSIFGIVVMILQFILPFVLIAISYIKI--WLFLNSR---------- 236

  Fly   385 GPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISG 449
                                      ||:
 Worm   237 --------------------------QSM------------------------------------ 239

  Fly   450 GGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDN 514
                                                                             
 Worm   240 ----------------------------------------------------------------- 239

  Fly   515 ESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPT 579
             :.|||                    .::.|||:::||.|:|:.|.|||.|..::|.:..|....
 Worm   240 -TERKS--------------------DIKRKKRLLRMLIVMVVIFAICWFPFNLLNCLRDLKLDN 283

  Fly   580 VYEYVGYTSISFL--QLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFWRR 640
            ...  ||.|..||  .|::.:::..|||.|.|||.:||..|...           .||.|.||
 Worm   284 FMR--GYFSFVFLSVHLMSMTATAWNPILYAFMNETFREEFAKV-----------VPCLFARR 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	99/456 (22%)
		TM helix 1	178..202	CDD:410628	9/23 (39%)
		TM helix 2	211..233	CDD:410628	8/21 (38%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	7/15 (47%)
		TM helix 5	340..363	CDD:410628	2/22 (9%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	10/26 (38%)
npr-6	NP_509725.2	7tmA_NPYR-like	39..322	CDD:320331	99/456 (22%)
		TM helix 1	39..65	CDD:320331	9/25 (36%)
		TM helix 2	72..97	CDD:320331	10/24 (42%)
		TM helix 3	110..140	CDD:320331	11/29 (38%)
		TM helix 4	156..177	CDD:320331	8/20 (40%)
		TM helix 5	203..232	CDD:320331	4/30 (13%)
		TM helix 6	247..277	CDD:320331	13/29 (45%)
		TM helix 7	290..315	CDD:320331	9/24 (38%)