Protein Alignment CCKLR-17D1 and npr-10

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001024487.1
• Gene: npr-10 / 183747
• WormBaseID: WBGene00008278
• Length: 365
• Species: Caenorhabditis elegans
• Alignment Length: 486
• Identity: 91/486 - (18%)
• Similarity: 167/486 - (34%)
• Gaps: 195/486 - (40%)

  Fly   174 VPIWVV-PCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTL 237
            :||.:: ..|:.|::..|.||||||:::::.:.::::.|:|:::|::|||.:.:....||.:...
 Worm    26 IPIAILATIYTIIVVVGVTGNLLVVMSVMRFKVLQSVRNMFIVSLSVSDIFVAIVSGSVTPITAF 90

  Fly   238 LRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLG 302
            .:.::||..||.|:...|..:::.|:.||.||:.:||..||||.:....:  :.|.|:|:.....
 Worm    91 SKVWLFGGPLCHLLPLLQGTALSFSTLTLTAIAIDRYILICHPTKEPIRK--DQALKMISFNSAI 153

  Fly   303 SLVCMTPIAAFSQLMPTSRPGLRKCREQWPADSLNYERA-YNLFLDLALLVLPLLALSFTYLFIT 366
            |:....|:....:||.........|.|.|..|:  |.|: |...:.:...|.||:.::|
 Worm   154 SVGLSVPLFMKQELMQFRNYCGEYCSENWGPDA--YLRSVYGTVVFIIQFVFPLITITF------ 210

  Fly   367 RTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHS 431
                                                                             
 Worm   211 ----------------------------------------------------------------- 210

  Fly   432 QYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRV 496
                                         |..|.|:|..|...:.|
 Worm   211 -----------------------------CYASISIKLRRGVFVRG------------------- 227

  Fly   497 HRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFI 561
                               |:::.:|:...::|:..||.:             :||.::.:.|.:
 Worm   228 -------------------SQKELMSEARRQLTQRRLRTN-------------RMLIIMTVTFAL 260

  Fly   562 CWTPLY-------------VINTMTMLLGPTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNAS 613
            .|.|..             :|::...|.| .::..:..||:           ..||..|.:.|..
 Worm   261 SWLPSVGFNFLRDYSALPGIIDSQDYLFG-IIFHCISMTSV-----------IVNPFLYGYCNEH 313

  Fly   614 FRRAF---VDTFK---GMR-------VCERL 631
            ||.||   :||.|   |||       .|.:|
 Worm   314 FRAAFAALLDTVKAACGMRRVSPGNPACSQL 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	79/455 (17%)
		TM helix 1	178..202	CDD:410628	9/24 (38%)
		TM helix 2	211..233	CDD:410628	7/21 (33%)
		TM helix 3	249..271	CDD:410628	7/21 (33%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	6/23 (26%)
		TM helix 6	549..571	CDD:410628	6/34 (18%)
		TM helix 7	586..611	CDD:410628	5/24 (21%)
npr-10	NP_001024487.1	7tmA_NPYR-like	29..318	CDD:320331	79/455 (17%)
		TM helix 1	30..56	CDD:320331	9/25 (36%)
		TM helix 2	63..88	CDD:320331	8/24 (33%)
		TM helix 3	101..131	CDD:320331	10/29 (34%)
		TM helix 4	142..163	CDD:320331	5/20 (25%)
		TM helix 5	189..218	CDD:320331	9/128 (7%)
		TM helix 6	242..272	CDD:320331	7/42 (17%)
		TM helix 7	286..311	CDD:320331	7/36 (19%)