Protein Alignment CCKLR-17D1 and npr-35

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001023088.2
• Gene: npr-35 / 183681
• WormBaseID: WBGene00016842
• Length: 384
• Species: Caenorhabditis elegans
• Alignment Length: 527
• Identity: 98/527 - (18%)
• Similarity: 169/527 - (32%)
• Gaps: 203/527 - (38%)

  Fly   167 VVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPV 231
            ::|.|..:.:.....|.|:....|:||..|||.:..::.:...|:..:|:||::|:.:...|:|.
 Worm    24 LLRHSYQLTVLYTVAYGAVFFTGVLGNTFVVLAVWAHKNLNITTDYLILSLALADLFILWICLPT 88

  Fly   232 TLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKII 296
            ||:.::...:::|:..|:|..:|.|::...|.:||||::.:||.||||.|:..|.....:...:|
 Worm    89 TLINSIFTEWLWGQFFCRLSTWANASTSFASVYTLVAVTADRYLAICHTLKYNTSWDREYTKYVI 153

  Fly   297 AIIWLGSLVCMTP------IAAFSQLMPTSRPGLRKCREQWPADSLNYERAYNLFLDLAL-LVLP 354
            ..:||.:.:...|      :..:.:    ...|.|.|..|      ..::.|.||::|.| .::|
 Worm   154 FAVWLVAAIFGIPNWYNYDLIVWQE----GSYGYRLCTSQ------TDQKLYFLFVNLLLAFIVP 208

  Fly   355 --LLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIV 417
              |::..:|.:|||                     |:|..|.||.....:.|.
 Worm   209 FGLISGLYTRIFIT---------------------VSTHRSLAVDARAREDRV------------ 240

  Fly   418 PHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTL 482
                                                                             
 Worm   241 ----------------------------------------------------------------- 240

  Fly   483 SGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKR 547
                                                                          |.|
 Worm   241 --------------------------------------------------------------KLR 243

  Fly   548 VVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGYTSI---SFLQLLAYSSSCCNPITYCF 609
            |..|:..:::.|..||.|||.|.|..........:....||:   ...|.::..||..|||.|..
 Worm   244 VATMMLTVIIVFACCWLPLYCIFTYFFFFADQRSDLFQITSMLIRPIFQWMSLLSSSLNPIIYIA 308

  Fly   610 MNASFRRAFVDTFKGMRVCERLCAPC---------CFWRRRS---KNETNLSVAGNSIALANSVM 662
            .:..:||||...         |..||         ...||.|   |:...:|::.......|...
 Worm   309 YSHKYRRAFKSI---------LLMPCKTRYERVRSTILRRHSRGFKSTATISMSNFGTEPTNLGG 364

  Fly   663 SSHTILE 669
            :|..::|
 Worm   365 ASSLLIE 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	83/452 (18%)
		TM helix 1	178..202	CDD:410628	8/23 (35%)
		TM helix 2	211..233	CDD:410628	6/21 (29%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	4/21 (19%)
		TM helix 5	340..363	CDD:410628	8/25 (32%)
		TM helix 6	549..571	CDD:410628	8/21 (38%)
		TM helix 7	586..611	CDD:410628	9/27 (33%)
npr-35	NP_001023088.2	7tm_GPCRs	33..317	CDD:475119	83/453 (18%)
		TM helix 1	35..59	CDD:410628	8/23 (35%)
		TM helix 2	68..90	CDD:410628	6/21 (29%)
		TM helix 3	106..128	CDD:410628	8/21 (38%)
		TM helix 4	151..167	CDD:410628	3/15 (20%)
		TM helix 5	194..217	CDD:410628	7/22 (32%)
		TM helix 6	245..267	CDD:410628	8/21 (38%)
		TM helix 7	285..310	CDD:410628	7/24 (29%)