Protein Alignment CCKLR-17D1 and Npy1r

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_035064.1
• Gene: Npy1r / 18166
• MGIID: 104963
• Length: 382
• Species: Mus musculus
• Alignment Length: 509
• Identity: 115/509 - (22%)
• Similarity: 181/509 - (35%)
• Gaps: 214/509 - (42%)

  Fly   182 YSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGEL 246
            |.|:::..|.|||.:::.:::.:.||.:||:.::||:.||:|:.|.|:|.|.|.||:.|::|||.
Mouse    46 YGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLMDHWVFGET 110

  Fly   247 LCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTIN-HANKIIAIIWLGSLVCMTPI 310
            :|||..|.|..|:.||.::||.|:.||:..|.:|   |.|:..| ||...|.:||:.::....|.
Mouse   111 MCKLNPFVQCVSITVSIFSLVLIAVERHQLIINP---RGWRPNNRHAYIGITVIWVLAVASSLPF 172

  Fly   311 AAFSQLM--PTSRPGLRK------CREQWPADSLNYERAYNLFLDLALLVL----PLLALSFTYL 363
            ..:..|.  |.....|..      |.:::|:||      :.|.....||||    ||..:...|.
Mouse   173 VIYQILTDEPFQNVSLAAFKDKYVCFDKFPSDS------HRLSYTTLLLVLQYFGPLCFIFICYF 231

  Fly   364 FITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHH 428
                .:|:.::                            ||.|     .:|.|
Mouse   232 ----KIYIRLK----------------------------RRNN-----MMDKI------------ 247

  Fly   429 HHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECC 493
            ..|:|
Mouse   248 RDSKY------------------------------------------------------------ 252

  Fly   494 SRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLE 558
                                                     ||:||      ||:..||..:|:.
Mouse   253 -----------------------------------------RSSET------KRINIMLLSIVVA 270

  Fly   559 FFICWTPLYVINTMTMLLGPTVYEY----VGYTSISFLQLL----AYSSSCCNPITYCFMNASFR 615
            |.:||.||.:.|        ||:::    :...:.:.|.||    |..|:|.|||.|.|:|.:|:
Mouse   271 FAVCWLPLTIFN--------TVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQ 327

  Fly   616 R--AFVDTFKGMRVCERLCAPCCFWRRRSKNET------NLSVAGNSIALANSV 661
            |  .|...|            |.|..|....||      :..|:..|:..|:.|
Mouse   328 RDLQFFFNF------------CDFRSRDDDYETIAMSTMHTDVSKTSLKQASPV 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	104/458 (23%)
		TM helix 1	178..202	CDD:410628	6/19 (32%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	10/21 (48%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	7/26 (27%)
		TM helix 6	549..571	CDD:410628	8/21 (38%)
		TM helix 7	586..611	CDD:410628	11/28 (39%)
Npy1r	NP_035064.1	7tmA_NPY1R	40..330	CDD:320517	104/456 (23%)
		TM helix 1	41..67	CDD:320517	6/20 (30%)
		TM helix 2	74..99	CDD:320517	11/24 (46%)
		TM helix 3	112..142	CDD:320517	13/29 (45%)
		TM helix 4	153..174	CDD:320517	6/20 (30%)
		TM helix 5	207..236	CDD:320517	9/32 (28%)
		TM helix 6	255..285	CDD:320517	14/43 (33%)
		TM helix 7	298..323	CDD:320517	11/24 (46%)