Protein Alignment CCKLR-17D1 and tkr-3

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001343603.1
• Gene: tkr-3 / 177285
• WormBaseID: WBGene00006428
• Length: 400
• Species: Caenorhabditis elegans
• Alignment Length: 525
• Identity: 95/525 - (18%)
• Similarity: 180/525 - (34%)
• Gaps: 183/525 - (34%)

  Fly   141 DMDLATT-----PSSSTLAPAVTVRTPGNRSVVRVS-ADVPIWVVPCYSAILLCAVVGNLLVVLT 199
            |..||:|     ..:..||.|......|:.....:: .::.||.: .|:.|...||||||||:..
 Worm     7 DSILASTITTVIGGAGVLAEAGEAELSGDDDFYELTPVELIIWCM-LYAIIAFMAVVGNLLVLYI 70

  Fly   200 LVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSW 264
            .:...|:|:||..|:|||..:|:..|:|.:|......|.:.:.....||:::.:.:..::.||.:
 Worm    71 TLFRLRVRSITTYFILNLGFADLFTGIFAIPFKFQAALFQEWFLPRSLCRIVPYVETVALTVSVF 135

  Fly   265 TLVAISCER----YYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFS---QLMPTSRP 322
            |||..:...    :::.|..:..|:      |.:.:.:||:.:::...|...|.   :....:..
 Worm   136 TLVTSAVHEFRTMFFSKCSQMSPRS------AKRCVLLIWIMAVLVSLPHGLFHNTYEFPDDNNT 194

  Fly   323 GLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPE 387
            .:.:|...:|  ...:.:.||::|.:....:|::.
 Worm   195 SIVQCLPVYP--DAGWWKTYNVYLVIIQYFVPMII------------------------------ 227

  Fly   388 VTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGP 452
                                     |||
 Worm   228 -------------------------LDT------------------------------------- 230

  Fly   453 CEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESR 517
                  .|.|.:..:.||..                     |||.....:|..|:...|
 Worm   231 ------AYTMIAVKIWSLSQ---------------------SRVELDETKMATQKISVV------ 262

  Fly   518 RKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTML--LGPTV 580
              |:..|:.::::                 :::.|.::|..|.:||.||   .|..:|  |.|.:
 Worm   263 --SMVSPNTQLSQ-----------------LMRTLIIVVACFSLCWFPL---ETYLLLNELKPEI 305

  Fly   581 --YEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFWRRRSK 643
              ::|:... ..|...||.|:||.|||.|...|..:...:...|:.:.         |.|:|:..
 Worm   306 NGWKYINLV-FFFSHWLAMSNSCLNPIIYGLYNTKYNEEYRRLFRQIG---------CIWQRQKS 360

  Fly   644 NETNL 648
            .:.::
 Worm   361 LDDSM 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	82/451 (18%)
		TM helix 1	178..202	CDD:410628	10/23 (43%)
		TM helix 2	211..233	CDD:410628	8/21 (38%)
		TM helix 3	249..271	CDD:410628	5/21 (24%)
		TM helix 4	294..310	CDD:410628	2/15 (13%)
		TM helix 5	340..363	CDD:410628	4/22 (18%)
		TM helix 6	549..571	CDD:410628	7/21 (33%)
		TM helix 7	586..611	CDD:410628	10/24 (42%)
tkr-3	NP_001343603.1	7tm_GPCRs	47..344	CDD:475119	83/453 (18%)
		TM helix 1	49..73	CDD:320515	11/24 (46%)
		TM helix 2	82..104	CDD:320515	8/21 (38%)
		TM helix 3	120..142	CDD:320515	5/21 (24%)
		TM helix 4	163..179	CDD:320515	2/15 (13%)
		TM helix 5	210..233	CDD:320515	7/120 (6%)
		TM helix 6	275..297	CDD:320515	8/24 (33%)
		TM helix 7	312..337	CDD:320515	10/25 (40%)