Protein Alignment CCKLR-17D1 and Grpr

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_032203.1
• Gene: Grpr / 14829
• MGIID: 95836
• Length: 384
• Species: Mus musculus
• Alignment Length: 509
• Identity: 115/509 - (22%)
• Similarity: 174/509 - (34%)
• Gaps: 211/509 - (41%)

  Fly   138 LNLDMDLATTPSSSTLAPAVTVRTPGNRSVVRVSAD---VP--IWVVPC-YSAILLCAVVGNLLV 196
            ||||:|           |.::.....|:|:.....|   .|  |:|:|. |..|::..::||:.:
Mouse     9 LNLDVD-----------PFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNITL 62

  Fly   197 VLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAV 261
            :......:.||.:.|:|:.:||:.|:||.|.|.||.....|...::||.:.||||.|.|..||.|
Mouse    63 IKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGV 127

  Fly   262 SSWTLVAISCERYYAICHPLRSRTWQTINHANKII----AIIWLGSLVCMTPIAAFSQLMP---- 318
            |.:||.|:|.:||.||..|:..:.    :||...|    |:||:.|::...|.|.||.|.|
Mouse   128 SVFTLTALSADRYKAIVRPMDIQA----SHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVK 188

  Fly   319 -TSRPGLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFG 382
             |::..: .| ..:|..:..:.:.:::...|...|:||..:|..|.||.|.|..|..|.
Mouse   189 DTNQTFI-SC-APYPHSNELHPKIHSMASFLVFYVIPLAIISVYYYFIARNLIQSAYNL------ 245

  Fly   383 SSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLI 447
                                                                             
Mouse   246 ----------------------------------------------------------------- 245

  Fly   448 SGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVS 512
                |.||..|:
Mouse   246 ----PVEGNIHV----------------------------------------------------- 253

  Fly   513 DNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLG 577
                                      .|.:||:||:.|.:.|.|..|..||.|.:||
Mouse   254 --------------------------KKQIESRKRLAKTVLVFVGLFAFCWLPNHVI-------- 284

  Fly   578 PTVYEYVGY-------------TSISFLQLLAYSSSCCNPITYCFMNASFRRAF 618
               |.|..|             |||. .:|||:::||.||.....::.|||:.|
Mouse   285 ---YLYRSYHYSEVDTSMLHFVTSIC-ARLLAFTNSCVNPFALYLLSKSFRKQF 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	103/463 (22%)
		TM helix 1	178..202	CDD:410628	6/24 (25%)
		TM helix 2	211..233	CDD:410628	11/21 (52%)
		TM helix 3	249..271	CDD:410628	12/21 (57%)
		TM helix 4	294..310	CDD:410628	5/19 (26%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	11/37 (30%)
Grpr	NP_032203.1	7tmA_GRPR	42..334	CDD:320252	103/463 (22%)
		TM helix 1	43..69	CDD:320252	6/25 (24%)
		TM helix 2	76..102	CDD:320252	11/25 (44%)
		TM helix 3	114..144	CDD:320252	17/29 (59%)
		TM helix 4	156..176	CDD:320252	5/19 (26%)
		TM helix 5	208..233	CDD:320252	6/24 (25%)
		TM helix 6	258..288	CDD:320252	14/40 (35%)
		TM helix 7	302..327	CDD:320252	10/25 (40%)