Protein Alignment CCKLR-17D1 and Ednrb

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_031930.1
• Gene: Ednrb / 13618
• MGIID: 102720
• Length: 442
• Species: Mus musculus
• Alignment Length: 567
• Identity: 108/567 - (19%)
• Similarity: 177/567 - (31%)
• Gaps: 252/567 - (44%)

  Fly   148 PSSSTLA----------PAVTVRTPG-NRSVVRVSADVPI-------------WVVPC------- 181
            |:.:||:          |..|..|.| |.|::|.||...:             :..||
Mouse    33 PAQATLSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRGAGVPPRSFPPPCQRNIEIS 97

  Fly   182 -----YSAILLC-----AVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGT 236
                 .:.|:.|     .::||..::..:.:|:.||...|:.:.:||:.|:|..:..:|:.....
Mouse    98 KTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINTYKL 162

  Fly   237 LLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSR-----TWQTINHANKII 296
            |...:.||..:|||:.|.|.|||.::..:|.|:|.:||.|:....|.:     .|..:.     |
Mouse   163 LAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVE-----I 222

  Fly   297 AIIWLGSLVCMTPIAAFSQLMPTSRPG--LRKCREQWPADSLN----------YERAYNLFLDLA 349
            .:||:.|:|...|.|....::.:...|  ||.|       .||          |:.|.:.:|...
Mouse   223 VLIWVVSVVLAVPEAIGFDMITSDYKGKPLRVC-------MLNPFQKTAFMQFYKTAKDWWLFSF 280

  Fly   350 LLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLD 414
            ...|||...:..|..:|                                           |:.|
Mouse   281 YFCLPLAITAVFYTLMT-------------------------------------------CEML- 301

  Fly   415 TIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGG 479
                                                                             
Mouse   302 ----------------------------------------------------------------- 301

  Fly   480 GTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLES 544
                                                 |:||..|.:|            ...|:.
Mouse   302 -------------------------------------RKKSGMQIAL------------NDHLKQ 317

  Fly   545 KKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVG---YTSISFLQLLAY-------SS 599
            ::.|.|.:|.|||.|.:||.||:    ::.:|..|:|:...   ...:|||.:|.|       .:
Mouse   318 RREVAKTVFCLVLVFALCWLPLH----LSRILKLTLYDQSNPHRCELLSFLLVLDYIGINMASLN 378

  Fly   600 SCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPC-CFWRRRSKNE 645
            ||.|||....::..|:..|       :.|  ||..| .|..::|..|
Mouse   379 SCINPIALYLVSKRFKNCF-------KSC--LCCWCQTFEEKQSLEE 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	88/484 (18%)
		TM helix 1	178..202	CDD:410628	6/40 (15%)
		TM helix 2	211..233	CDD:410628	6/21 (29%)
		TM helix 3	249..271	CDD:410628	9/21 (43%)
		TM helix 4	294..310	CDD:410628	5/15 (33%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	10/21 (48%)
		TM helix 7	586..611	CDD:410628	10/31 (32%)
Ednrb	NP_031930.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..84		9/33 (27%)
		7tmA_ET-BR	102..397	CDD:320642	86/468 (18%)
		TM helix 1	103..129	CDD:320642	4/25 (16%)
		TM helix 2	136..162	CDD:320642	6/25 (24%)
		TM helix 3	174..204	CDD:320642	14/29 (48%)
		TM helix 4	216..236	CDD:320642	6/24 (25%)
		TM helix 5	270..295	CDD:320642	6/24 (25%)
		TM helix 6	316..346	CDD:320642	11/33 (33%)
		TM helix 7	365..390	CDD:320642	7/24 (29%)