Protein Alignment CCKLR-17D1 and Brs3

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_033896.2
• Gene: Brs3 / 12209
• MGIID: 1100501
• Length: 399
• Species: Mus musculus
• Alignment Length: 547
• Identity: 106/547 - (19%)
• Similarity: 186/547 - (34%)
• Gaps: 207/547 - (37%)

  Fly   146 TTPSSSTLAPAVTVR------TPGNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNR 204
            |..|||.::...|.:      :||      :.|...|::.  |:.|:...::||.:::....:.:
Mouse    20 TETSSSVVSNDTTHKGWTGDNSPG------IEALCAIYIT--YAGIISVGILGNAILIKVFFKTK 76

  Fly   205 RMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAI 269
            .|:|:.|:|:.:||..|:||.:.|:||.....|...::||::.||::.|.:..||.||.:||..:
Mouse    77 SMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTIL 141

  Fly   270 SCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLM----PTSRPGLRKCREQ 330
            |.:||.|:..||..:....|.........||:.|::...|.|.||.:.    |........| ..
Mouse   142 SADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESC-NS 205

  Fly   331 WPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAA 395
            :|......:..::|...|...::||..:|..|..|.||||.|..|
Mouse   206 YPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLN-------------------- 250

  Fly   396 VAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLY 460
                                 :|.:...|.:
Mouse   251 ---------------------IPTEEQSHAR---------------------------------- 260

  Fly   461 CMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPS 525
                                                                             
Mouse   261 ----------------------------------------------------------------- 260

  Fly   526 LRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTP---LYVINTMTMLLGPTVYE-YVGY 586
                          |.:||:||:.|.:.|||..|.:||.|   ||:.::.|       || |..:
Mouse   261 --------------KQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFT-------YESYANH 304

  Fly   587 TSISFL-----QLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFWRRRSKNE- 645
            :.:.|:     ::||:|:||.||....:::.:|::.|....            ||....:.:..
Mouse   305 SDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQL------------CCLKAEQPEPPL 357

  Fly   646 -----TNLSVAGNSIALANSVMSSHTI 667
                 .||:|.|...|..::.:|..::
Mouse   358 GDIPLNNLTVMGRVPATGSAHVSEISV 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	88/453 (19%)
		TM helix 1	178..202	CDD:410628	4/23 (17%)
		TM helix 2	211..233	CDD:410628	10/21 (48%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	10/24 (42%)
		TM helix 7	586..611	CDD:410628	8/29 (28%)
Brs3	NP_033896.2	7tm_GPCRs	48..341	CDD:475119	89/456 (20%)
		TM helix 1	50..74	CDD:320251	5/25 (20%)
		TM helix 2	83..105	CDD:320251	10/21 (48%)
		TM helix 3	121..143	CDD:320251	8/21 (38%)
		TM helix 4	166..182	CDD:320251	3/15 (20%)
		TM helix 5	215..238	CDD:320251	5/22 (23%)
		TM helix 6	270..292	CDD:320251	9/21 (43%)
		TM helix 7	309..334	CDD:320251	8/24 (33%)