Protein Alignment CCKLR-17D1 and GPR83

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_057624.3
• Gene: GPR83 / 10888
• HGNCID: 4523
• Length: 423
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 111/514 - (21%)
• Similarity: 183/514 - (35%)
• Gaps: 193/514 - (37%)

  Fly   178 VVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFI 242
            ::..||.|::.::.||:||...:.:|:||.:.|::|::|||::||::.:...|.|||..:...:|
Human    74 LIVAYSFIIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMITLLNTPFTLVRFVNSTWI 138

  Fly   243 FGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCM 307
            ||:.:|.:.:|||..|:.||:.||.||:.:|:..|.|||:.|.  :|......||:||..:....
Human   139 FGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPRI--SITKGVIYIAVIWTMATFFS 201

  Fly   308 TPIAAFSQL--MPTSRPGLRK-CREQW--PADSLNYERAYNLFLDLA----LLVLPLLALSFTYL 363
            .|.|...:|  ...|...:|. |...:  |||      .:..:||||    |.:||||.:|..|.
Human   202 LPHAICQKLFTFKYSEDIVRSLCLPDFPEPAD------LFWKYLDLATFILLYILPLLIISVAYA 260

  Fly   364 FITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHH 428
            .:.:.|::                                      |..:..:...|
Human   261 RVAKKLWL--------------------------------------CNMIGDVTTEQ-------- 279

  Fly   429 HHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECC 493
                 |:
Human   280 -----YF---------------------------------------------------------- 281

  Fly   494 SRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLE 558
                                                  .|||        .||:.:|||.::|:.
Human   282 --------------------------------------ALRR--------KKKKTIKMLMLVVVL 300

  Fly   559 FFICWTPLYVINTMTMLLGPTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFK 623
            |.:||.||   |...:||...|.........:| ...|.||:|.||..||::|.:||   ::...
Human   301 FALCWFPL---NCYVLLLSSKVIRTNNALYFAF-HWFAMSSTCYNPFIYCWLNENFR---IELKA 358

  Fly   624 GMRVCERLCAP------------CCFWRRRSKNETNLSVAGNSIALANSVMSSHTILES 670
            .:.:|:|...|            ...|  ..||:...:...|::...:.:.|..|.|.|
Human   359 LLSMCQRPPKPQEDRPPSPVPSFRVAW--TEKNDGQRAPLANNLLPTSQLQSGKTDLSS 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	100/448 (22%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	7/21 (33%)
		TM helix 3	249..271	CDD:410628	10/21 (48%)
		TM helix 4	294..310	CDD:410628	4/15 (27%)
		TM helix 5	340..363	CDD:410628	10/26 (38%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	9/24 (38%)
GPR83	NP_057624.3	7tmA_GPR83	72..356	CDD:320511	100/451 (22%)
		TM helix 1	73..99	CDD:320511	7/24 (29%)
		TM helix 2	106..131	CDD:320511	10/24 (42%)
		TM helix 3	144..174	CDD:320511	12/29 (41%)
		TM helix 4	185..206	CDD:320511	5/20 (25%)
		TM helix 5	236..265	CDD:320511	11/28 (39%)
		TM helix 6	285..315	CDD:320511	13/40 (33%)
		TM helix 7	324..349	CDD:320511	9/25 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	402..423		4/14 (29%)