Protein Alignment CCKLR-17D1 and npy2r

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_004911210.1
• Gene: npy2r / 100498351
• XenbaseID: XB-GENE-983413
• Length: 408
• Species: Xenopus tropicalis
• Alignment Length: 507
• Identity: 112/507 - (22%)
• Similarity: 195/507 - (38%)
• Gaps: 190/507 - (37%)

  Fly   137 DLNLDMDL------ATTPSSSTLAPAVTVRTPGNRSVVRVSADVPIWVVPCYSAILLCAVVGNLL 195
            |:..:|:.      .|||.:....|.:.       .:.:: ..|.:.::..||:|:|..|:||.|
 Frog    37 DIKTEMNTWFYAAGLTTPYNDLTKPELI-------DITKL-LSVQVVLILAYSSIILLGVLGNSL 93

  Fly   196 VVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVA 260
            |:..:::.:.|||:||.|::|||:||:::...|:|.|||.|||..:.||.:||.|:.::|..:|.
 Frog    94 VIYVVIKFKTMRTVTNFFIVNLAVSDLMVNTLCLPFTLVYTLLDDWKFGTVLCHLVTYSQGLAVQ 158

  Fly   261 VSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAF---SQLMPTSRP 322
            ||:.||:.|:.:|:..|.:.|.|:....|  ...||.|.|:.|.:..:|:|.|   |.::.:|..
 Frog   159 VSTVTLMVIALDRHRCIVYHLESKISTKI--CFMIIGITWVCSALLASPLAIFKEYSVIVISSDF 221

  Fly   323 GLRKCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPE 387
            .::.|.|:||...|||...|::.:.|...::||..:|:.|:    .::..::|.
 Frog   222 QIQACSERWPVGDLNYGTIYSISMLLIQYIVPLAIISYAYI----RIWTKLKNH----------- 271

  Fly   388 VTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGP 452
                                                                       :|.||
 Frog   272 -----------------------------------------------------------VSPGG- 276

  Fly   453 CEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESR 517
              |..|.            ||:                                          |
 Frog   277 --GNDHY------------HQR------------------------------------------R 285

  Fly   518 RKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTV-- 580
            ||:                            .|||..:|:.|.:||.|.:.....:.:.|..:
 Frog   286 RKT----------------------------TKMLVAVVVVFAVCWLPFHAFQLASDIDGKVLDL 322

  Fly   581 --YEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCER 630
              |:.: ||   ...::|..|:..||:.|.:||.::|.||:..||    ||:
 Frog   323 NEYKLI-YT---IFHVIAMCSTFANPLLYGWMNNNYRTAFLTAFK----CEQ 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	99/447 (22%)
		TM helix 1	178..202	CDD:410628	9/23 (39%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	5/15 (33%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	8/21 (38%)
		TM helix 7	586..611	CDD:410628	7/24 (29%)
npy2r	XP_004911210.1	7tmA_NPY2R	74..358	CDD:320521	99/448 (22%)
		TM helix 1	75..101	CDD:320521	9/25 (36%)
		TM helix 2	108..133	CDD:320521	12/24 (50%)
		TM helix 3	146..176	CDD:320521	10/29 (34%)
		TM helix 4	187..208	CDD:320521	7/22 (32%)
		TM helix 5	238..267	CDD:320521	6/32 (19%)
		TM helix 6	283..313	CDD:320521	12/99 (12%)
		TM helix 7	326..351	CDD:320521	7/28 (25%)