Protein Alignment CCKLR-17D1 and prlhr

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_002940396.1
• Gene: prlhr / 100497660
• XenbaseID: XB-GENE-994391
• Length: 343
• Species: Xenopus tropicalis
• Alignment Length: 502
• Identity: 104/502 - (20%)
• Similarity: 173/502 - (34%)
• Gaps: 178/502 - (35%)

  Fly   143 DLATTPSSSTLAPAVTVRTPGNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMR 207
            :::||.|   |.||:...:......:::.......::||||.::...:.||.|::..:.:.::|.
 Frog     5 NISTTQS---LFPAMASNSSQQFMGLQLIHSYKALIIPCYSLVVFTGIFGNYLLIYVICRTKKMH 66

  Fly   208 TITNVFLLNLAISDILLGVFCMPVTLVGTL-LRHFIFGELLCKLIQFAQAASVAVSSWTLVAISC 271
            .:||..:.|||.||:|:...|:|:||.... .|.::||..||..:...|..:|.||.:||..|:.
 Frog    67 NVTNFLVGNLAFSDMLMCATCVPLTLAYVFEPRGWVFGHFLCYFVFLMQPVTVYVSVFTLTVIAV 131

  Fly   272 ERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTSRPGLRKCREQW---PA 333
            :||:|..:|||.|.  ||.....|:|.|||.|.:...|..|.:..:...:.....|.|.|   ..
 Frog   132 DRYHATVYPLRRRL--TIPTCAYILAGIWLLSCLMAAPALAHTYHVEFPQLDFSICEEFWFGMEK 194

  Fly   334 DSLNYERAYN-LFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVA 397
            ..|.|  ||: |.|..|   ||.:.::.:||.|:    |.::|.
 Frog   195 KRLAY--AYSTLILTYA---LPFIIIALSYLRIS----VKLKNR--------------------- 229

  Fly   398 EAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCM 462
                              :||
 Frog   230 ------------------VVP-------------------------------------------- 232

  Fly   463 RSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLR 527
                             |.::...|                        ..:.:||
 Frog   233 -----------------GNITNVQA------------------------EWDRARR--------- 247

  Fly   528 ITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGYTSISFL 592
                              |:..::|.::|..|.:||.||::.|.|..:    ....:.....:.:
 Frog   248 ------------------KKTFRLLVLVVGAFGMCWLPLHIFNIMKDI----DIHLIDKQYFNLV 290

  Fly   593 QL----LAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPC 635
            ||    ||..|:|.|.:.|.:::.|||......|...|......|||
 Frog   291 QLLCHWLAMMSACTNSLLYAWLHDSFRGELKKMFLWKRKRIGPTAPC 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	93/449 (21%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	7/21 (33%)
		TM helix 4	294..310	CDD:410628	6/15 (40%)
		TM helix 5	340..363	CDD:410628	7/23 (30%)
		TM helix 6	549..571	CDD:410628	7/21 (33%)
		TM helix 7	586..611	CDD:410628	8/28 (29%)
prlhr	XP_002940396.1	7tmA_PrRP_R	35..320	CDD:320516	93/450 (21%)
		TM helix 1	36..62	CDD:320516	7/25 (28%)
		TM helix 2	69..94	CDD:320516	12/24 (50%)
		TM helix 3	108..138	CDD:320516	11/29 (38%)
		TM helix 4	149..170	CDD:320516	7/20 (35%)
		TM helix 5	196..225	CDD:320516	12/37 (32%)
		TM helix 6	245..275	CDD:320516	11/56 (20%)
		TM helix 7	288..313	CDD:320516	8/24 (33%)