Protein Alignment CCKLR-17D1 and cckar

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_017945081.1
• Gene: cckar / 100492455
• XenbaseID: XB-GENE-992615
• Length: 432
• Species: Xenopus tropicalis
• Alignment Length: 458
• Identity: 148/458 - (32%)
• Similarity: 219/458 - (47%)
• Gaps: 124/458 - (27%)

  Fly   182 YSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGEL 246
            ||.|.|.:|:||.||:..|::|:||||:||:|||:||:||::|.:||||.||:..|||.||||..
 Frog    52 YSLIFLLSVLGNSLVIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLRDFIFGSA 116

  Fly   247 LCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIA 311
            :||...:....||:||::.|||||.|||.|||.||:||.|||.:||.|:||..|..|...|:|..
 Frog   117 VCKAATYFMGISVSVSTFNLVAISLERYSAICKPLQSRVWQTKSHALKVIAATWCLSFAIMSPYP 181

  Fly   312 AFSQLMPTSRPGLR---KCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSM 373
            .:|.|:|.::...|   .||..||:|..  ::::.:||.|.|.::|.:.::..|..|:..||..:
 Frog   182 IYSTLVPLNKIQNRTANMCRLLWPSDLT--QQSWYVFLLLILFLVPGIVMTIAYGLISMELYRGI 244

  Fly   374 RNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYG 438
            :.|.                       |||:.
 Frog   245 KFEM-----------------------SQRKE--------------------------------- 253

  Fly   439 HCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQM 503
                                    ||:|:.|  :|..||.|            |..:..:.|:::
 Frog   254 ------------------------RSSSISS--NQFKNGDG------------CYLQSIKKRKKL 280

  Fly   504 QLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYV 568
            ::.|..            |..|.:|..  :|.::...:|.:||||::||.|:|:.|||||||::.
 Frog   281 EMHQLS------------SHHSAKIER--VRSNSSAANLMAKKRVIRMLIVIVILFFICWTPVFS 331

  Fly   569 INTMTMLLGPTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCA 633
            .|........:....:....|||:.||:|:|:|.|||.|||||..||..|:.||
 Frog   332 ANAWRAFDTDSADISLSGVPISFIHLLSYTSACVNPIIYCFMNKRFRMGFLATF----------- 385

  Fly   634 PCC 636
            .||
 Frog   386 TCC 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	143/438 (33%)
		TM helix 1	178..202	CDD:410628	10/19 (53%)
		TM helix 2	211..233	CDD:410628	13/21 (62%)
		TM helix 3	249..271	CDD:410628	9/21 (43%)
		TM helix 4	294..310	CDD:410628	6/15 (40%)
		TM helix 5	340..363	CDD:410628	5/22 (23%)
		TM helix 6	549..571	CDD:410628	11/21 (52%)
		TM helix 7	586..611	CDD:410628	14/24 (58%)
cckar	XP_017945081.1	7tmA_CCK-AR	46..381	CDD:320644	143/438 (33%)
		TM helix 1	47..73	CDD:320644	10/20 (50%)
		TM helix 2	80..106	CDD:320644	16/25 (64%)
		TM helix 3	118..148	CDD:320644	15/29 (52%)
		TM helix 4	161..182	CDD:320644	9/20 (45%)
		TM helix 5	210..239	CDD:320644	7/28 (25%)
		TM helix 6	306..336	CDD:320644	16/29 (55%)
		TM helix 7	349..374	CDD:320644	14/24 (58%)