Protein Alignment CCKLR-17D1 and oprk1

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001305708.1
• Gene: oprk1 / 100489465
• XenbaseID: XB-GENE-1011503
• Length: 420
• Species: Xenopus tropicalis
• Alignment Length: 496
• Identity: 94/496 - (18%)
• Similarity: 174/496 - (35%)
• Gaps: 186/496 - (37%)

  Fly   163 GNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVF 227
            ||.:  .:|..:.:.:...||.:.:..:|||.||:..:::..:|:|.||:::.|||::|.|: ..
 Frog    66 GNHT--SISPTISVIITAVYSMVFVVGLVGNALVMFVIIRYTKMKTATNIYIFNLALADALV-TT 127

  Fly   228 CMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHA 292
            .||......|:..:.||::|||::......::..|.:||..:|.:||.|:|||:::..::|...|
 Frog   128 TMPFQSTSFLMNSWPFGDVLCKIVVSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKA 192

  Fly   293 NKIIAIIW-LGSLVCMTPIAAFSQLMPTSRPGLRKCREQWPADSLNYERAYNLFLDLALLVLPLL 356
            ..|...|| |.|.|.::.|......:   ..|..:|..|:|.....::....:.:.:...::|:.
 Frog   193 KCINICIWMLSSSVGISAIVLGGTKI---SDGSTECALQFPTHYWYWDTVMKMCVFIFAFIIPVF 254

  Fly   357 ALSFTY-LFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQ 420
            .::..| |.|.|...|
 Frog   255 IITICYTLMILRLKSV------------------------------------------------- 270

  Fly   421 HNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGT 485
                                    ||:||
 Frog   271 ------------------------RLLSG------------------------------------ 275

  Fly   486 GAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVK 550
                                          ||.|.                      .:.:|:.:
 Frog   276 ------------------------------SREKD----------------------RNLRRITR 288

  Fly   551 MLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGYTSISFLQL-LAYSSSCCNPITYCFMNASF 614
            ::.|:|..|.:||||:::...:..|:  .|.:.:...||.:..: |.|::|..|||.|.|::.:|
 Frog   289 LVLVVVAVFIVCWTPIHIFVLVEALV--DVPQSIAVVSIYYFCIALGYTNSSLNPILYAFLDENF 351

  Fly   615 RRAFVDTFKGMRVCERLCAPCCFWRRRSKNETNLSVAGNSI 655
            :|.|.|          .|.|.   :.|...:.| |..||::
 Frog   352 KRCFKD----------FCFPS---KHRLDRQPN-SRVGNTV 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	82/443 (19%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	8/21 (38%)
		TM helix 3	249..271	CDD:410628	4/21 (19%)
		TM helix 4	294..310	CDD:410628	6/16 (38%)
		TM helix 5	340..363	CDD:410628	2/23 (9%)
		TM helix 6	549..571	CDD:410628	7/21 (33%)
		TM helix 7	586..611	CDD:410628	10/25 (40%)
oprk1	NP_001305708.1	7tmA_Kappa_opioid_R	77..355	CDD:320219	82/444 (18%)
		TM helix 1	78..104	CDD:320219	7/25 (28%)
		TM helix 2	111..137	CDD:320219	9/26 (35%)
		TM helix 3	148..178	CDD:320219	9/29 (31%)
		TM helix 4	190..212	CDD:320219	7/21 (33%)
		TM helix 5	237..266	CDD:320219	4/28 (14%)
		TM helix 6	281..311	CDD:320219	8/29 (28%)
		TM helix 7	323..348	CDD:320219	10/24 (42%)
		YihI	<362..>408	CDD:470104	5/21 (24%)