Protein Alignment CCKLR-17D1 and tacr3

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_002934808.1
• Gene: tacr3 / 100486525
• XenbaseID: XB-GENE-985728
• Length: 431
• Species: Xenopus tropicalis
• Alignment Length: 555
• Identity: 116/555 - (20%)
• Similarity: 188/555 - (33%)
• Gaps: 203/555 - (36%)

  Fly   144 LATTPSSSTLAPAVTVRTPGNRSVV-------RVSADV------PIWVVP----CYSAILLCAVV 191
            :.:.|::.|....:.:..|....|:       .||:.|      |.|.:.    .|.:::..||.
 Frog     1 MTSMPTNLTTGEVIGIFAPLGEGVLWPNSTQRNVSSPVAHKFVQPPWRIALWSLAYGSMVAVAVF 65

  Fly   192 GNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQA 256
            ||::|:..::.::||||:||.||:|||.||..:..|...|..:..|...:.|||..|:...|...
 Frog    66 GNIIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHNEWYFGEAYCRFHNFFPI 130

  Fly   257 ASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTSR 321
            .|:..|.:::.||:.:||.||..||:.|...|  ....:|..||:.:::...|...:|::..|..
 Frog   131 TSIFASIYSMSAIAVDRYMAIIDPLKPRLSAT--STKVVIGSIWIFAILLAFPQCLYSKIRVTRT 193

  Fly   322 PGLRKCREQWPADSLNYER-AYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSG 385
            ..|  |...||...   || .|...|.|.:.||||:.:..||..:..||:
 Frog   194 RTL--CMLVWPGKD---ERLTYQFILVLLVYVLPLIVMGVTYTIVGITLW--------------- 238

  Fly   386 PEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGG 450
                                                                             
 Frog   239 ----------------------------------------------------------------- 238

  Fly   451 GPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNE 515
                                        ||.:.      |:...:.|
 Frog   239 ----------------------------GGEIP------GDTSDKYH------------------ 251

  Fly   516 SRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVI---NTMTMLLG 577
                                    :.|.:|::||||:.|:|:.|.|||.|.::.   :.:.:.|.
 Frog   252 ------------------------EQLRAKRKVVKMMIVVVVTFAICWLPYHIFFLADALDIKLD 292

  Fly   578 PTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFWRRRS 642
            ...|....|.:|.:   ||.||:..|||.||.:|..||..|...|:.          |.|....|
 Frog   293 RWKYIQQIYLAIFW---LAMSSTMYNPIIYCCLNKRFRAGFKRAFRW----------CPFIEVSS 344

  Fly   643 KNETNLS------VAGNSIALANSVMSSHTILESP 671
            .:|..|.      ...:|:...:.:.||.|::..|
 Frog   345 YDELELKSTRFHPTRQSSLYTVSRMESSMTVVFDP 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	96/448 (21%)
		TM helix 1	178..202	CDD:410628	6/27 (22%)
		TM helix 2	211..233	CDD:410628	10/21 (48%)
		TM helix 3	249..271	CDD:410628	5/21 (24%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	9/23 (39%)
		TM helix 6	549..571	CDD:410628	10/24 (42%)
		TM helix 7	586..611	CDD:410628	11/24 (46%)
tacr3	XP_002934808.1	7tm_GPCRs	50..330	CDD:475119	95/445 (21%)
		TM helix 1	52..76	CDD:320669	6/23 (26%)
		TM helix 2	85..107	CDD:320669	10/21 (48%)
		TM helix 3	123..145	CDD:320669	5/21 (24%)
		TM helix 4	166..182	CDD:320669	3/15 (20%)
		TM helix 5	208..231	CDD:320669	8/22 (36%)
		TM helix 6	261..283	CDD:320669	10/21 (48%)
		TM helix 7	298..323	CDD:320669	11/27 (41%)