Protein Alignment CCKLR-17D1 and grpr

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_002938295.1
• Gene: grpr / 100486428
• XenbaseID: XB-GENE-1013137
• Length: 384
• Species: Xenopus tropicalis
• Alignment Length: 555
• Identity: 124/555 - (22%)
• Similarity: 189/555 - (34%)
• Gaps: 204/555 - (36%)

  Fly   138 LNLDMDLATTPSSSTLAPAVTVRTPGNRSVVRVSAD-----VPIWVVPCYSAILLCAVVGNLLVV 197
            |:|:.|.|.|  ||.|          |:|....|.|     |...:||.|..|:|..::||:.::
 Frog     9 LDLEADFALT--SSCL----------NQSSNHSSDDWFYPGVTYAIVPVYGIIILIGLIGNITLI 61

  Fly   198 LTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVS 262
            ......:.||.:.|:|:.:||:.|:||.|.|.||.....|...::||.:.||||.|.|..||.||
 Frog    62 KIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRFLADKWLFGRVGCKLIPFIQLTSVGVS 126

  Fly   263 SWTLVAISCERYYAICHPLRSRTWQTINHANKI---IAIIWLGSLVCMTPIAAFSQLMPTSRPGL 324
            .:||.|::.:||.||..|:   ..|..|...||   .|:||:.|:....|.|.||.:.|.....:
 Frog   127 VFTLTALAADRYTAIVRPM---DIQANNALTKICIKAALIWILSMTLAIPEAVFSDMHPFYDKEI 188

  Fly   325 R----KCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSG 385
            .    .| ..:|..:..:.|.::....|...|:||..:|..|.||.:.|
 Frog   189 NVTFVSC-APYPHSNGLHPRIHSTTSFLIFYVIPLSIISVYYYFIAKNL---------------- 236

  Fly   386 PEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGG 450
                                                                             
 Frog   237 ----------------------------------------------------------------- 236

  Fly   451 GPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNE 515
                       |||||     :..:.|                 .||..||
 Frog   237 -----------MRSAS-----NMPVEG-----------------NVHVRRQ-------------- 254

  Fly   516 SRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTV 580
                                      :||:||:.|.:.|.|..|..||.|:::|.....
 Frog   255 --------------------------IESRKRLAKTVLVFVGLFAFCWLPIHIIYLYRS------ 287

  Fly   581 YEY-------VGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFW 638
            |.|       :.|.|....::||:::||.||.....::.|||:    .|.....|   |.|....
 Frog   288 YHYSEVDTSVLHYISSICARVLAFTNSCVNPFALYLLSKSFRK----QFNNQLFC---CRPRLIV 345

  Fly   639 RRRSKNETNLSVAGNSIALANSVMSSHTILESPRL 673
            |.:|...:...:  .|:...|..|:|.:::....:
 Frog   346 RTQSMGRSTTRM--TSLKSTNHSMASFSLINGKHI 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	101/454 (22%)
		TM helix 1	178..202	CDD:410628	7/23 (30%)
		TM helix 2	211..233	CDD:410628	11/21 (52%)
		TM helix 3	249..271	CDD:410628	12/21 (57%)
		TM helix 4	294..310	CDD:410628	6/18 (33%)
		TM helix 5	340..363	CDD:410628	6/22 (27%)
		TM helix 6	549..571	CDD:410628	8/21 (38%)
		TM helix 7	586..611	CDD:410628	8/24 (33%)
grpr	XP_002938295.1	7tmA_GRPR	40..332	CDD:320252	101/459 (22%)
		TM helix 1	41..67	CDD:320252	7/25 (28%)
		TM helix 2	74..100	CDD:320252	11/25 (44%)
		TM helix 3	112..142	CDD:320252	16/29 (55%)
		TM helix 4	154..174	CDD:320252	6/19 (32%)
		TM helix 5	206..231	CDD:320252	7/24 (29%)
		TM helix 6	256..286	CDD:320252	12/29 (41%)
		TM helix 7	300..325	CDD:320252	8/24 (33%)