Protein Alignment CCKLR-17D1 and qrfprl2

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: XP_002935352.5
• Gene: qrfprl2 / 100486271
• XenbaseID: XB-GENE-952811
• Length: 431
• Species: Xenopus tropicalis
• Alignment Length: 453
• Identity: 94/453 - (20%)
• Similarity: 159/453 - (35%)
• Gaps: 175/453 - (38%)

  Fly   182 YSAILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGEL 246
            |..|.:.|:.||.|||..:::.:.|||:||:|:.::|.||:|:..||:|.||:..:...::.|..
 Frog    53 YIIIFILALFGNSLVVYIIIRKKAMRTVTNIFICSMACSDLLVTFFCIPFTLLQNISSEWLGGRF 117

  Fly   247 LCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIA 311
            :||::.|.|..:|..|:.|:..|:.|||..|.|||:.:...|...|.|::..:|..::|..:|:
 Frog   118 VCKMVPFIQTTAVVASTLTMTCIAVERYQGIVHPLKMKRQYTNIRAYKMLGCVWSVAIVVGSPM- 181

  Fly   312 AFSQLMPTSRPGLRK-----CREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYV 371
            ...|.:......|..     |.|.|  ..:...|||.:|:.:||.::||.|:...|..|...|::
 Frog   182 LHVQTLEVKYDLLYNLYHVCCLESW--SDVELRRAYAIFILVALFLVPLAAMLLLYTRIGYELWI 244

  Fly   372 SMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYD 436
            ..|                        .|.        |..|:|
 Frog   245 KKR------------------------VGD--------CSVLNT--------------------- 256

  Fly   437 YGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQ 501
                                                                             
 Frog   257 ----------------------------------------------------------------- 256

  Fly   502 QMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFICWTPL 566
                                           |.|:...|....|||.|.|:.::||.|..||.|.
 Frog   257 -------------------------------LSRNEMAKITRKKKRAVMMMVIVVLFFTACWAPF 290

  Fly   567 YVINTMTMLLGPTVYEYVGYTS----------ISFLQLLAYSSSCCNPITYCFMNASFRRAFV 619
            :|::.:        :||.....          ::.:|.:.:.:|..||:.|.|||.:|:::.|
 Frog   291 HVVHIL--------FEYNNLEDEYDDVTVKMIVAIVQAVGFFNSFNNPVVYTFMNENFKKSLV 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	93/450 (21%)
		TM helix 1	178..202	CDD:410628	8/19 (42%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	7/21 (33%)
		TM helix 4	294..310	CDD:410628	3/15 (20%)
		TM helix 5	340..363	CDD:410628	9/22 (41%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	6/34 (18%)
qrfprl2	XP_002935352.5	7tmA_QRFPR	48..343	CDD:320333	93/449 (21%)
		TM helix 1	48..74	CDD:320333	8/20 (40%)
		TM helix 2	81..107	CDD:320333	12/25 (48%)
		TM helix 3	119..149	CDD:320333	11/29 (38%)
		TM helix 4	162..183	CDD:320333	5/21 (24%)
		TM helix 5	212..237	CDD:320333	10/24 (42%)
		TM helix 6	267..297	CDD:320333	12/37 (32%)
		TM helix 7	312..337	CDD:320333	6/24 (25%)