Protein Alignment CCKLR-17D1 and kissr2

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001165296.1
• Gene: kissr2 / 100329185
• XenbaseID: XB-GENE-29077375
• Length: 369
• Species: Xenopus tropicalis
• Alignment Length: 470
• Identity: 107/470 - (22%)
• Similarity: 178/470 - (37%)
• Gaps: 161/470 - (34%)

  Fly   164 NRSVVRVSADVP------IWVVPCYSA-ILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISD 221
            |.|:|..:...|      .|:||.:.| |:|..::||.||:..:.::|:|||.||.::.|||.:|
 Frog    21 NESLVNRTETGPPPFLTDAWLVPLFFALIMLVGLIGNSLVIYVISKHRQMRTATNFYIANLASTD 85

  Fly   222 ILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTW 286
            |:..|.|:|.|.....|..::||:.:||.:.:.|..:|..:..||.|:|.:|.||..:||||...
 Frog    86 IMFLVCCVPFTATLYPLPSWVFGDFMCKFVAYLQQVTVQATCITLTAMSADRCYATLYPLRSLRH 150

  Fly   287 QTINHANKIIAIIWLGSLVCMTPIAAFSQLMPTSRPGLRK-CREQWPADSLNYERAYNLFLDLAL 350
            :|...|..:...||:|||:..|||..:.::......|.|. |.||:|:|.:  ::...|:..||:
 Frog   151 RTPKVAMIVSICIWIGSLLLSTPIIPYQKIQKGYWYGPRTYCIEQFPSDVM--KKVCILYQFLAV 213

  Fly   351 LVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDT 415
            .:||||.:...|..:.:.:               |..|
 Frog   214 YLLPLLTICLCYSLMLKRV---------------GRPV--------------------------- 236

  Fly   416 IVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGG 480
            :.|..:|
 Frog   237 VEPTDNN---------------------------------------------------------- 243

  Fly   481 TLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESK 545
                                .|:||               ||:                :::..:
 Frog   244 --------------------YQVQL---------------LSE----------------RTIAMR 257

  Fly   546 KRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVGYTSISFLQLLAYSSSCCNPITYCFM 610
            .::.||:.|:||.|.|||.|:.:.:............|..|...::...::|::|..||:.|.||
 Frog   258 SKISKMVIVIVLLFTICWGPIQLFSLFQGFYPGFQANYATYKIKTWANCMSYANSSINPLVYAFM 322

  Fly   611 NASFRRAFVDTFKGM 625
            .||||::|...|..|
 Frog   323 GASFRKSFKKAFPFM 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	100/442 (23%)
		TM helix 1	178..202	CDD:410628	9/24 (38%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	6/21 (29%)
		TM helix 4	294..310	CDD:410628	6/15 (40%)
		TM helix 5	340..363	CDD:410628	7/22 (32%)
		TM helix 6	549..571	CDD:410628	10/21 (48%)
		TM helix 7	586..611	CDD:410628	7/24 (29%)
kissr2	NP_001165296.1	7tmA_KiSS1R	40..330	CDD:320223	100/442 (23%)
		TM helix 1	41..67	CDD:320223	9/25 (36%)
		TM helix 2	74..100	CDD:320223	11/25 (44%)
		TM helix 3	112..142	CDD:320223	11/29 (38%)
		TM helix 4	154..174	CDD:320223	7/19 (37%)
		TM helix 5	202..231	CDD:320223	8/28 (29%)
		TM helix 6	255..285	CDD:320223	10/29 (34%)
		TM helix 7	298..323	CDD:320223	7/24 (29%)