Protein Alignment CCKLR-17D1 and kissr1b

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001165295.1
• Gene: kissr1b / 100329184
• XenbaseID: XB-GENE-29077371
• Length: 367
• Species: Xenopus tropicalis
• Alignment Length: 491
• Identity: 107/491 - (21%)
• Similarity: 177/491 - (36%)
• Gaps: 175/491 - (35%)

  Fly   174 VPIWVVPCYSA-ILLCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTL 237
            |..|:||.:.| |:|..:|||.||:..:.::|:|||:||.::.|||.:||...|.|:|.|.....
 Frog    43 VDAWLVPLFFALIMLVGLVGNSLVIYVISKHRQMRTVTNFYIANLATTDITFLVCCVPFTATLYP 107

  Fly   238 LRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLG 302
            |..::||:.:|:.:.:.|..:...:..||.|:|.:|.|...:||:|...:|...|..:...||:|
 Frog   108 LPSWVFGDFMCRCVNYLQQVTAQATCITLTAMSVDRCYVTVYPLQSLRHRTPRMAMAVSLGIWIG 172

  Fly   303 SLVCMTPIAAFSQLMPTSRPGLRK-CREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFIT 366
            |.|...|.|.:.:|......|.:. |.|.:|  ::.:::|:.|:..||:.:||||.:...|.|:.
 Frog   173 SFVLSIPFAMYQKLSTGYWYGPQTYCIEAFP--TVLHQKAFILYTFLAVYLLPLLTICICYAFML 235

  Fly   367 RTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHS 431
            :.:               |..|                           :.|..:|
 Frog   236 KRM---------------GRPV---------------------------VEPIDNN--------- 249

  Fly   432 QYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRV 496
                                                                             
 Frog   250 ----------------------------------------------------------------- 249

  Fly   497 HRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFI 561
                .|:||..:                               :|...:.::.:|:.|:||.|.|
 Frog   250 ----YQVQLLAE-------------------------------RSEAMRTKISRMVVVIVLLFTI 279

  Fly   562 CWTPLYVINTMTMLLGPTVYEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMR 626
            ||.|:.:..............|..|....|...::||:|..|||.|.||.|:||::|...|
 Frog   280 CWGPVQLFILFQAFDSSFEKSYETYKLKIFAHCMSYSNSSINPIVYAFMGANFRKSFKKAF---- 340

  Fly   627 VCERLCAPCCFWRRRSKNETNLSVAGNSIALANSVM 662
                   |..|.:|         |.|.:..:||:.|
 Frog   341 -------PFIFKQR---------VEGTAGVVANTEM 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	96/442 (22%)
		TM helix 1	178..202	CDD:410628	10/24 (42%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	4/21 (19%)
		TM helix 4	294..310	CDD:410628	5/15 (33%)
		TM helix 5	340..363	CDD:410628	8/22 (36%)
		TM helix 6	549..571	CDD:410628	9/21 (43%)
		TM helix 7	586..611	CDD:410628	10/24 (42%)
kissr1b	NP_001165295.1	7tmA_KiSS1R	46..336	CDD:320223	96/442 (22%)
		TM helix 1	47..73	CDD:320223	10/25 (40%)
		TM helix 2	80..106	CDD:320223	11/25 (44%)
		TM helix 3	118..148	CDD:320223	8/29 (28%)
		TM helix 4	160..180	CDD:320223	6/19 (32%)
		TM helix 5	208..237	CDD:320223	10/28 (36%)
		TM helix 6	261..291	CDD:320223	9/29 (31%)
		TM helix 7	304..329	CDD:320223	10/24 (42%)