Protein Alignment CCKLR-17D1 and kiss1r

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001163985.1
• Gene: kiss1r / 100316929
• XenbaseID: XB-GENE-990075
• Length: 366
• Species: Xenopus tropicalis
• Alignment Length: 499
• Identity: 113/499 - (22%)
• Similarity: 187/499 - (37%)
• Gaps: 181/499 - (36%)

  Fly   174 VPIWVVPCYSAIL-LCAVVGNLLVVLTLVQNRRMRTITNVFLLNLAISDILLGVFCMPVTLVGTL 237
            |..|:||.:.|:| |..:.||.||:..:.::::|||:||.::.|||.:||:..|.|:|.|.....
 Frog    40 VDAWLVPLFFAMLMLVGLTGNSLVIYVISKHKQMRTVTNFYIANLAATDIIFLVSCVPFTAALYP 104

  Fly   238 LRHFIFGELLCKLIQFAQAASVAVSSWTLVAISCERYYAICHPLRSRTWQTINHANKIIAIIWLG 302
            |..:||||.:||.:.:.|..||..:..||.|:|.:|:|...:||:|...:|...|..:...||:|
 Frog   105 LPGWIFGEFMCKFVNYIQQVSVQATCVTLTAMSVDRWYVTVYPLQSLRQRTPRVAAAVSVGIWIG 169

  Fly   303 SLVCMTPIAAFSQLMPTSRPGLR-KCREQWPADSLNYERAYNLFLDLALLVLPLLALSFTYLFIT 366
            |.:...|:..::||:.....|.: .|.|.:|  |:::|:|:.|:..|.:.:|||:.:...|
 Frog   170 SFIVSIPVPIYNQLIEGYWFGPQIYCSESFP--SVSHEKAFILYNFLVVYLLPLITICICY---- 228

  Fly   367 RTLYVSMRNERAMNFGSSGPEVTTSSSAAVAEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHS 431
                                      ||.|
 Frog   229 --------------------------SAMV----------------------------------- 232

  Fly   432 QYYYDYGHCGSKRRLISGGGPCEGRRHLYCMRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRV 496
                                        |.|...||:.:
 Frog   233 ----------------------------YQMGRPSVEPV-------------------------- 243

  Fly   497 HRMRQQMQLQQQGYVSDNESRRKSLSQPSLRITEAGLRRSNETKSLESKKRVVKMLFVLVLEFFI 561
                            ||..:.:.|::                :|...:.::.:|:.|:||.|.|
 Frog   244 ----------------DNSYQVQLLAE----------------RSELMRTKISRMVAVIVLLFTI 276

  Fly   562 CWTP--LYVINTMTMLLGPTV-YEYVGYTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFK 623
            ||.|  ||:   :.....|:. .:|..|....:...::|::|..|||.|.||.|:||:||...|
 Frog   277 CWGPIQLYI---LFQAFSPSFKRDYYTYKVKIWANCMSYTNSSINPIVYAFMGANFRKAFNKVF- 337

  Fly   624 GMRVCERLCAPCCFWRRRSKNETNLSVAGNSIALANSVMSSHTI 667
                      |..|.:|         |....:|.||:....|.:
 Frog   338 ----------PFLFKQR---------VGSTGVANANANTEMHFV 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	101/445 (23%)
		TM helix 1	178..202	CDD:410628	9/24 (38%)
		TM helix 2	211..233	CDD:410628	9/21 (43%)
		TM helix 3	249..271	CDD:410628	7/21 (33%)
		TM helix 4	294..310	CDD:410628	4/15 (27%)
		TM helix 5	340..363	CDD:410628	6/22 (27%)
		TM helix 6	549..571	CDD:410628	11/23 (48%)
		TM helix 7	586..611	CDD:410628	8/24 (33%)
kiss1r	NP_001163985.1	7tmA_KiSS1R	43..333	CDD:320223	101/445 (23%)
		TM helix 1	44..70	CDD:320223	9/25 (36%)
		TM helix 2	77..103	CDD:320223	11/25 (44%)
		TM helix 3	115..145	CDD:320223	11/29 (38%)
		TM helix 4	157..177	CDD:320223	5/19 (26%)
		TM helix 5	205..234	CDD:320223	11/121 (9%)
		TM helix 6	258..288	CDD:320223	11/32 (34%)
		TM helix 7	301..326	CDD:320223	8/24 (33%)