Protein Alignment CCKLR-17D1 and cckbra

DIOPT Version :10

• Sequence 1: NP_001097021.1
• Gene: CCKLR-17D1 / 32860
• FlyBaseID: FBgn0259231
• Length: 673
• Species: Drosophila melanogaster
• Sequence 2: NP_001108186.2
• Gene: cckbra / 100137117
• ZFINID: ZDB-GENE-060503-482
• Length: 444
• Species: Danio rerio
• Alignment Length: 527
• Identity: 156/527 - (29%)
• Similarity: 241/527 - (45%)
• Gaps: 135/527 - (25%)

  Fly   140 LDMDLATTPSSSTLAPAVTVRTPGNRSVVRVSADVPIWVVPCYSAILLCAVVGNLLVVLTLVQNR 204
            |.:::..|.|::::........|.....||:.         .||.:.|.:|.||||:::.|:.|:
Zfish    30 LSVEVNATCSNASIIQKFKPTRPKEMDSVRII---------LYSLVFLLSVFGNLLIIVVLIVNK 85

  Fly   205 RMRTITNVFLLNLAISDILLGVFCMPVTLVGTLLRHFIFGELLCKLIQFAQAASVAVSSWTLVAI 269
            ||||:||.|||:||:||:::.:||:|..|:.:||..||||..:||.:.:....||::|:::||||
Zfish    86 RMRTVTNSFLLSLAVSDLMMAIFCIPFNLIPSLLEDFIFGAAMCKTVAYFMGISVSISTFSLVAI 150

  Fly   270 SCERYYAICHPLRSRTWQTINHANKIIAIIWLGSLVCMTPIAAFSQLMP---TSRPGLRKCREQW 331
            :.|||.|||:||:||.|||.:||.|:||..|:.|:..|.|...||.|:|   |:......||.:|
Zfish   151 AIERYSAICNPLKSRAWQTRSHAYKVIAATWVLSVAIMVPYPVFSILVPFNKTNNITAHMCRLEW 215

  Fly   332 PADSLNYERAYNLFLDLALLVLPLLALSFTYLFITRTLYVSMRNERAMNFGSSGPEVTTSSSAAV 396
            |...:  |:.:.:.|...|..:|.:.:...|..|:|.||..::.|......:||.:
Zfish   216 PISQV--EQTWYVLLLSILFFIPGVVMIIAYGLISRELYRGIQFELEQKKDTSGVK--------- 269

  Fly   397 AEAGSQRRANGSHCQSLDTIVPHQHNPHQQHHHHSQYYYDYGHCGSKRRLISGGGPCEGRRHLYC 461
                     ||
Zfish   270 ---------NG------------------------------------------------------ 271

  Fly   462 MRSASVKSLRHQQINGGGGTLSGTGAGNGECCSRVHRMRQQMQLQQQGYVSDNESRRKSLSQPSL 526
                         :|||   ||.....:..|..:|.:....|:|.
Zfish   272 -------------LNGG---LSSCHDESDGCYIQVSKKPPAMELS-------------------- 300

  Fly   527 RITEAG-----LRRSNETKS-LESKKRVVKMLFVLVLEFFICWTPLYVINTMTMLLGPTVYEYVG 585
            .:|.:|     ..|||.::: |.:||||::||.::|..||:||.|||..||.......:....:.
Zfish   301 TLTTSGPVKTDRPRSNTSEAKLIAKKRVIRMLIIIVAMFFVCWMPLYSANTWKAFDQISAQRALS 365

  Fly   586 YTSISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGMRVCERLCAPCCFWRRRSKNETNLS- 649
            ...|||:|||:|:|:|.|||.|||||..||:|.:.||   ..|.|   ||...|:|.:.:..::
Zfish   366 GAPISFIQLLSYTSACVNPIIYCFMNTRFRKALLATF---GCCRR---PCHNRRKRKEGDDEITG 424

  Fly   650 VAGNSIA 656
            |.|.||:
Zfish   425 VTGVSIS 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKLR-17D1	NP_001097021.1	7tm_GPCRs	177..618	CDD:475119	137/449 (31%)
		TM helix 1	178..202	CDD:410628	9/23 (39%)
		TM helix 2	211..233	CDD:410628	11/21 (52%)
		TM helix 3	249..271	CDD:410628	8/21 (38%)
		TM helix 4	294..310	CDD:410628	6/15 (40%)
		TM helix 5	340..363	CDD:410628	3/22 (14%)
		TM helix 6	549..571	CDD:410628	10/21 (48%)
		TM helix 7	586..611	CDD:410628	15/24 (63%)
cckbra	NP_001108186.2	7tmA_CCK-BR	57..398	CDD:320645	139/459 (30%)
		TM helix 1	58..84	CDD:320645	11/34 (32%)
		TM helix 2	91..117	CDD:320645	13/25 (52%)
		TM helix 3	129..159	CDD:320645	13/29 (45%)
		TM helix 4	172..193	CDD:320645	9/20 (45%)
		TM helix 5	221..250	CDD:320645	6/28 (21%)
		TM helix 6	323..353	CDD:320645	16/29 (55%)
		TM helix 7	366..391	CDD:320645	15/24 (63%)