Protein Alignment Cyp308a1 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_573320.1
• Gene: Cyp308a1 / 32859
• FlyBaseID: FBgn0030949
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 145/624 - (23%)
• Similarity: 232/624 - (37%)
• Gaps: 198/624 - (31%)

  Fly     3 PLVLFILLAATLLFWKWQG----NHWRRLGLEAPFGWPLVGNMLDFALG--------RRSYGEIY 55
            |:|...|..|.|...||..    :...:|||..|...|.:||:..|..|        |:.||.:
Human    14 PMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPL- 77

  Fly    56 QEIYTRNPGLKYVGFY---RLFNEPAILVRDQELLRQILV------------GRNFADCADNAVY 105
                        .|:|   |:|    |::.:.::::|:||            |..|...||:.::
Human    78 ------------CGYYLGRRMF----IVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLF 126

  Fly   106 VDHQRDVLASHNPFIANGDRWRVLRADLVPLFTPSRVRQ-------------------------- 144
            :   ||            .||..:|..|:..|:|.::.:
Human   127 L---RD------------KRWEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPT 176

  Fly   145 ---------------TLPH-----VARACQLL-----RDQVPLGRFEAKDLATRYTLQVVASAIF 184
                           |||.     :::||.||     |.......|:.:.....||..||||..|
Human   177 RLSKPSGIYVNLHYATLPFCMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAF 241

  Fly   185 G--LDA----------HCLGIHMRVAHEPSRWLEWLAPLFQPSVWSLLETMSLLHTPRLGRLIGH 237
            |  :|:          ||           .|:.|:..|  :|.:..||...|:: .| |.|::.:
Human   242 GTPVDSWQAPEDPFVKHC-----------KRFFEFCIP--RPILVLLLSFPSIM-VP-LARILPN 291

  Fly   238 RYVPLPLQHWFRELVE----------ARSGGDNLLQWLAESK----------------------- 269
            :... .|..:|.:|:.          |.....:.||.:.:::
Human   292 KNRD-ELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGC 355

  Fly   270 --------------RGLGKEELAGHATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIELDEV 320
                          |.|..:|:.|.|...|:.|||.....|:||.|.||.|.|.|.:|..|:|..
Human   356 KPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVF 420

  Fly   321 AQRHAGNLIDPVALGELRYSEAALLEALRLHPAMQALQKRCTKTFTLPDQKSGASSELKVHLGTV 385
            .::|.......:..| |.|.:..:.|.||::|......:...:...:..|        ::..|.|
Human   421 KEKHMAPEFCSLEEG-LPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ--------RIPAGAV 476

  Fly   386 LVLPVQAIHLDPALYPAPNQFRPERFLNQPPMGCR---FLGFGAGPRMCPGMRLGLLQTKAALTT 447
            |.:.|.|:|.||..:|:|..|.||||..:.....|   :|.||||||.|.|:|||||:.|..|..
Human   477 LEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLH 541

  Fly   448 LLQDHCVQLADEDQCRVEVSPLTFLTASRNGIWLSFKRR 486
            :|.....|...|.|..:::...:.| ..:||:::....|
Human   542 VLHKFRFQACPETQVPLQLESKSAL-GPKNGVYIKIVSR 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp308a1	NP_573320.1	CYP6-like	63..480	CDD:410679	125/544 (23%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	127/557 (23%)