Protein Alignment Cyp308a1 and CYP3A43

DIOPT Version :9

• Sequence 1: NP_573320.1
• Gene: Cyp308a1 / 32859
• FlyBaseID: FBgn0030949
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 118/522 - (22%)
• Similarity: 220/522 - (42%)
• Gaps: 105/522 - (20%)

  Fly     7 FILLAATLLFWKWQGNH----WRRLGLEAPFGWPLVGNMLDFALGRRSYGEIYQEIYTRNPGLKY 67
            ::|:|.:|:.....|.|    :::||:..|...|.:|.:|.:..|..::.....|.|....|| |
Human    12 WVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGL-Y 75

  Fly    68 VGFYRLFNEPAILVRDQELLRQILVGRNFADCADNAVYVDHQRDVLASHNPF-----------IA 121
            .|     .:|.:::.|.::::.:||...::              |..:..|.           .|
Human    76 EG-----QQPMLVIMDPDMIKTVLVKECYS--------------VFTNQMPLGPMGFLKSALSFA 121

  Fly   122 NGDRWRVLRADLVPLFTPSRVRQTLPHVARACQL----LRDQVPLGR-FEAKDLATRYTLQVVAS 181
            ..:.|:.:|..|.|.||..:.::.:|.:::...:    ||.:....: ...||....||:.|:..
Human   122 EDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITG 186

  Fly   182 AIFGLDAHCLGIHMRVAHEPS----------RWLEWLAP---------------------LFQPS 215
            .:||::...|       :.|.          ..|::|.|                     ||...
Human   187 TLFGVNLDSL-------NNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKD 244

  Fly   216 VWSLLE-TMSLLHTPRLGRLIGHRYVPLPLQHWFRELVEARSGGDNLLQWLAESKRGLGKEELAG 279
            |...|: ::..:...||.....||.      .:|::::::::..:      .:|.:.|...||..
Human   245 VTHFLKNSIERMKESRLKDKQKHRV------DFFQQMIDSQNSKE------TKSHKALSDLELVA 297

  Fly   280 HATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIELDEVAQRHAGNLIDPVALGELRYSEAAL 344
            .:..::...|:|::..|.|.:||||.:.|.|::|..|:|.|....|....|  ||.::.|.:..:
Human   298 QSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYD--ALVQMEYLDMVV 360

  Fly   345 LEALRLHPAMQALQKRCTKTFTLPDQKSGASSELKVHLGTVLVLPVQAIHLDPALYPAPNQFRPE 409
            .|.|||.|.:..:.:.|.|...:        :.:.:..|..:::|:.|:|.||..:..|.:|.||
Human   361 NETLRLFPVVSRVTRVCKKDIEI--------NGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417

  Fly   410 -RF--LNQPPMGC-RFLGFGAGPRMCPGMRLGLLQTKAALTTLLQDHCVQLADEDQCRVEVSPLT 470
             ||  .|:..:.. |::.||||||.|.|||..|...|.|:...||:...:...|.|..:::..|.
Human   418 SRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 482

  Fly   471 FL 472
            .|
Human   483 IL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	111/493 (23%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	111/495 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820