DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp308a1 and cyp3c2

DIOPT Version :9

Sequence 1:	NP_573320.1	Gene:	Cyp308a1 / 32859	FlyBaseID:	FBgn0030949	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_021330384.1	Gene:	cyp3c2 / 558473	ZFINID:	ZDB-GENE-081103-62	Length:	503	Species:	Danio rerio

Alignment Length:	539	Identity:	132/539 - (24%)
Similarity:	233/539 - (43%)	Gaps:	140/539 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LFILLAATLLFW--KWQGNHWRRLGLEAPFGWPLVGNMLDFALG--------RRSYGEIYQEIYT 60
            :.::|..|||:.  .|....:::||:..|..||..|..|.:..|        .:.||:::
Zfish    12 ILVVLVLTLLYMYGVWPHGFFKKLGIPGPRPWPFFGTFLSYTKGFFNFDMECAKKYGKVW----- 71

  Fly    61 RNPGLKYVGFY--RLFNEPAILVRDQELLRQILVGRNFADCADNAVYVDHQRDVLASHNPFIANG 123
                    |.|  ||   |.::|.|.|:::.|:|    .:|...   ..::|::.......:|:|
Zfish    72 --------GIYDGRL---PILMVTDLEMIKTIMV----KECYST---FTNRREINVDLAGPLADG 118

  Fly   124 ------DRWRVLRADLVPLFTPSRVRQTLP----HVARACQLLR---DQVPLGRFEAKDLATRYT 175
                  :||:.:|..|.|.||..|:::..|    |..|..:.::   .:.|:   :.|::...|:
Zfish   119 ITAVKDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKGDHEQPV---KIKEVMASYS 180

  Fly   176 LQVVASAIFGLDAHCLGIHMRVAHEP--------SRWLEW--------LAPLFQPSVWSLLETMS 224
            |.||.|:.|.:|...:       :.|        ..:|::        |..:| ||:.:||..|.
Zfish   181 LDVVTSSAFSVDIDSI-------NNPDDPFVTNIKNFLKFNLFGLFVLLLTVF-PSIANLLGKMG 237

  Fly   225 LL--------------------HTPRLGRLIGHRYVPLPLQHWFRELVEARSGGDNLLQWLAES- 268
            |.                    |....||:           .:||.:::.....|.:....:|.
Zfish   238 LSMFSKPTVDFFYKALRKIKEEHKDSNGRV-----------DFFRLMIQNEIPDDQVKDTTSEQP 291

  Fly   269 KRGLGKEELAGHATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIELDEVAQRHAGN--LIDP 331
            ::||...|:...:...::.||||::..|.|.||.||:|.|...:|..::|:       |  |..|
Zfish   292 EKGLTDHEILSQSFIFIMGGYETTSTTLTFLLYNLAINPDCLEKLVEKIDK-------NFPLDTP 349

  Fly   332 V---ALGELRYSEAALLEALRLHPAMQALQKRCTKT-----FTLPDQKSGASSELKVHLGTVLVL 388
            :   ||.::.|.|.::.|::||.|....|::.|.||     .|:|..             |::.:
Zfish   350 ISYDALMKIDYLEMSINESMRLLPTAPRLERVCKKTVEMNGITIPKD-------------TMITI 401

  Fly   389 PVQAIHLDPALYPAPNQFRPERFLNQPP---MGCRFLGFGAGPRMCPGMRLGLLQTKAALTTLLQ 450
            |...::.||.|:.:|::||||||..:..   :...|:.||.|||.|.|||..|:..|..:..|||
Zfish   402 PTYVLNQDPQLWDSPHEFRPERFSPENKSEFLQYAFMPFGLGPRNCIGMRYALMIVKLLVVKLLQ 466

  Fly   451 DHCVQLADEDQCRVEVSPL 469
            :..|:...|.|..:|::|:
Zfish   467 NFSVETCKETQIPLELNPV 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	125/511 (24%)
cyp3c2	XP_021330384.1	p450	38..496	CDD:306555	125/513 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910