DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp308a1 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_573320.1	Gene:	Cyp308a1 / 32859	FlyBaseID:	FBgn0030949	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	525	Identity:	134/525 - (25%)
Similarity:	220/525 - (41%)	Gaps:	114/525 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLFILLAATLLFWKWQGNHWRRLGLEAPFGWPLVGNMLDFALGRRSYGEIYQEIYTRNPGLKYVG 69
            :|..|.|..:::..|...::::||:..|...|..|.||.:..|...:.....|.|.|..|: |.|
Zfish    10 LLAFLAALLVIYGSWPHRYFKKLGIPGPKAIPFFGTMLRYKDGFHVFDMDCFEKYGRIWGI-YDG 73

  Fly    70 FYRLFNEPAILVRDQELLRQILV---------GRNFADCADNAVYVDHQRDVLASHNPFIANGDR 125
                 .:|.:.:.||.:::.:|:         .|||.  .:.|:|     |.::     ||..|.
Zfish    74 -----RQPVLCIMDQTIIKTVLIKECYSLFTNRRNFR--LNGALY-----DAVS-----IAEDDD 121

  Fly   126 WRVLRADLVPLFTPSRVRQTLPHVARACQLLRDQVPLGR-------FEAKDLATRYTLQVVASAI 183
            ||.:|:.|.|.||..|:::....:.:...:|.|.  :|:       .:.|:....|::.||.|..
Zfish   122 WRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDS--MGKTAKRGESADIKEFFGAYSMDVVTSTA 184

  Fly   184 FGLDAHCLGIHMRVAHEP--------SRWLEW--LAPLFQ-----PSVWSLLETMSLLHTPRLGR 233
            |.:|...|       :.|        .:.|::  |.|||.     |.:..:||.|.....|
Zfish   185 FSVDIDSL-------NNPKDPFVTNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKMDFALFP---- 238

  Fly   234 LIGHRYVPLPLQHWFRELVEARSGGD-------------NLLQWLAES-------------KRGL 272
                   ......::..|.:.:|..|             :.||.:.:|             ::||
Zfish   239 -------TSVTDFFYAALQKIKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTEKGL 296

  Fly   273 GKEELAGHATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIELDEVAQRHAGNLIDPVALGEL 337
            ...|:...:...:..|||||:..|:|..|.||.|.:..::|..|:||.....|.  :|...|..:
Zfish   297 SDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPNQAP--VDYETLMSM 359

  Fly   338 RYSEAALLEALRLHPAMQALQKRCTKTFTLPDQKSGASSELKVHLGTVLVLPVQAIHLDPALYPA 402
            .|.:|||.|:|||.|....|::.|.||..:        :.|.:....|:::|..|:|.||..:..
Zfish   360 DYLDAALSESLRLFPVAARLERVCKKTVEI--------NGLLIPKDLVVMVPTYALHRDPDYWSE 416

  Fly   403 PNQFRPERFLN------QPPMGCRFLGFGAGPRMCPGMRLGLLQTKAALTTLLQDHCVQLADEDQ 461
            |..|:||||..      .|.|   ::.||.|||.|.|||...:..|.|:..:||...|.:.||.|
Zfish   417 PESFKPERFTKGNKESIDPYM---YMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQ 478

  Fly   462 CRVEV 466
            ..:|:
Zfish   479 VPLEL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	128/498 (26%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	128/500 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920