DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp308a1 and Cyp6a22

DIOPT Version :9

Sequence 1:	NP_573320.1	Gene:	Cyp308a1 / 32859	FlyBaseID:	FBgn0030949	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	516	Identity:	161/516 - (31%)
Similarity:	240/516 - (46%)	Gaps:	54/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPLVLFILLAATLLFW--KWQGNHWRRLGL-EAPFGWPLVGNMLDFALGRRSYGEIYQEIYT-- 60
            ||.:|..:|:|..:.||  :.:.::|.|.|: ..|..:| ||||..|...:. :.:|...||.
  Fly     1 MLDVVALLLIALAVGFWFVRTRYSYWTRRGIGSEPARFP-VGNMEGFRKNKH-FIDIVTPIYEKF 63

  Fly    61 RNPGLKYVGFYRLFNEPAILVRDQELLRQILVGRNFADCADNAVYVDHQRDVLASHNPFIANGDR 125
            :..|..:.||:.:. .|.:||.|.||.:|||: ::||:..|..:|.:.:.|.|..| .|..:|.:
  Fly    64 KGNGAPFAGFFMML-RPVVLVTDLELAKQILI-QDFANFEDRGMYHNERDDPLTGH-LFRIDGPK 125

  Fly   126 WRVLRADLVPLFTPSRVRQTLPHV-------ARACQLLRDQVPLGRFEAKDLATRYTLQVVASAI 183
            ||.||..:.|.||.::::...|.|       .:.|..|.|....|..|..||..|||..|:....
  Fly   126 WRPLRQKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCA 190

  Fly   184 FGLDAHCL-------GIHMRVAHEPSRWLEWLAPLFQPSVWSLLETMSLLHTPRLGRLIGHRYVP 241
            ||::.:.|       .|..|.|....|..:    |....:.|..|....|...::.:.|...||.
  Fly   191 FGVECNGLRNPEAEFAIMGRRAFSERRHCK----LVDGFIESFPEVARFLRMRQIHQDITDFYVG 251

  Fly   242 LPLQHWFRELVE-------ARSGGDNLLQWLAESKRG-LGKEELAGHATTLLLEGYETSAMLLAF 298
            :     .||.|:       .||...|||  :...:|| |..||:|..|......|::|||..|.|
  Fly   252 I-----VRETVKQREEQGIVRSDFMNLL--IEMKQRGELTIEEMAAQAFIFFAAGFDTSASTLGF 309

  Fly   299 ALYELALNEDAQRRLHIELDEVAQRHAGNLIDPVALGELRYSEAALLEALRLHPAMQALQKRCTK 363
            ||||||.....|.:|..|:|:..:.|.|..... ::.||||.|..:.|.||.:|.:..|.:....
  Fly   310 ALYELAKQPALQAKLREEIDQALRLHNGEFTYD-SMQELRYMELVIAETLRKYPILPQLTRISRH 373

  Fly   364 TFTLPDQKSGASSELKVHLGTVLVLPVQAIHLDPALYPAPNQFRPERF----LNQPPMGCRFLGF 424
            .:.....:     ...:..|.:|::||..||.||||||.|::|.||||    |.|.|... :|.|
  Fly   374 LYAAKGDR-----HFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFLADQLAQRPTAA-WLPF 432

  Fly   425 GAGPRMCPGMRLGLLQTKAALTTLLQDHCVQLADEDQCRVEVSPLTFLTASRNGIWLSFKR 485
            |.|||.|.|||.|.:||...|.:||::....:......::|......|....|||:|..::
  Fly   433 GDGPRNCIGMRFGKMQTTIGLVSLLRNFHFSVCPRTDPKIEFLKSNILLCPANGIYLKVQQ 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	150/476 (32%)
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	151/478 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460939
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900