DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp308a1 and Cyp6d2

DIOPT Version :9

Sequence 1:	NP_573320.1	Gene:	Cyp308a1 / 32859	FlyBaseID:	FBgn0030949	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	140/535 - (26%)
Similarity:	235/535 - (43%)	Gaps:	104/535 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPLVLFILLAATLL-FWKWQGNHWRRLGLE-----APFGWPLVGNMLDFALGR-RSYGEIYQEI 58
            |..::|.||:|..|. :.|....||:|||::     .|||      ::|..:.: ||.|....:|
  Fly     1 MWTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFG------VMDTVMKQERSLGMALADI 59

  Fly    59 YTRNPGLKYVGFYRLFNEPAILVRDQELLRQILVGRNFADCADNAVYVDHQRDVLASHNPFIANG 123
            |.|:.| |.||.|.| |:.:||:||.:|.|||:.. :||...|..||||..:|.| |.|.|...|
  Fly    60 YARHEG-KIVGIYML-NKRSILIRDAQLARQIMTS-DFASFHDRGVYVDEDKDPL-SANLFNLRG 120

  Fly   124 DRWRVLRADLVPLFTPSRVR-----------QTLPHVARACQLLRDQVPLGRFEAKDLATRYTLQ 177
            ..||.||..|.|.|:..:::           :.:.|:..|.. ..|:|     |.||:.|.|.:.
  Fly   121 ASWRNLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALD-QSDEV-----EIKDVMTTYAVD 179

  Fly   178 VVASAIFGLDAHCL----GIHMRVAHEPSRWLEWLAPLFQPSVWSLLETMSLLHTPRLGRL---I 235
            ::.|.||||:....    .....::...||         ..|:...:..||:...|.:.:|   :
  Fly   180 IIGSVIFGLEIDSFRNPKNEFREISSSTSR---------DESLLLKIHNMSMFICPPIAKLMNRL 235

  Fly   236 GHR-YVPLPLQHWFRELVEARS----------------------GGDNLLQW----LAESKRGLG 273
            |:. .:...|:...:..:|.|.                      |.|:...|    ..|..:.:.
  Fly   236 GYESRILTSLRDMMKRTIEFREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMS 300

  Fly   274 KEELAGHATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIELDEVAQRHAGNL-----IDPVA 333
            .|::|..|....:.|.|::|...||.||||::..:..:....|:|.|..:|  ||     ....|
  Fly   301 IEKIAAQAFLFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKH--NLKPKDRFTYEA 363

  Fly   334 LGELRYSEAALLEALRLHPAMQALQKRCTKTFTLPDQKSGASSELKVHL---GTVLVLPVQAIHL 395
            :.:|::.:..::|.:|.:|.:..|.:.||:.:.:|...         |:   ||.:::.:..:..
  Fly   364 VQDLKFLDICIMETIRKYPGLPFLNRECTEDYPVPGTN---------HIIAKGTPILISLFGMQR 419

  Fly   396 DPALYPAPNQFRPERF----LNQPPMGCRFLGFGAGPRMCPGMRLGLLQTKAALTTLLQ--DHCV 454
            ||..:|.||.:.|.||    :|...  ..::.||.|||.|..:|:|.:.:|.|:..:|.  |...
  Fly   420 DPVYFPNPNGYDPHRFDSNNMNYDQ--AAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQ 482

  Fly   455 QLADEDQCRVEVSPL 469
            ....|.:.|.:.:|:
  Fly   483 SPRKEVEFRFDAAPV 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	128/498 (26%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	118/465 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460853
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900